INT346567

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.25
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Sh3gl3) endosome (Sh3gl3) cytoplasm (Sh3gl3)
Anatomy Link Frequency
liver 1
tubules 1
heart 1
urine 1
Sh3gl3 (Mus musculus)
Pain Link Frequency Relevance Heat
peripheral neuropathy 21 61.28 Quite High
Peripheral nervous system 14 33.40 Quite Low
Neuropathic pain 14 21.68 Low Low
Spinal cord 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
analgesia 7 5.00 Very Low Very Low Very Low
hypoalgesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fabry Disease 126 98.48 Very High Very High Very High
Disease Progression 14 96.96 Very High Very High Very High
Gauchers Disease 49 92.44 High High
Nociception 21 72.24 Quite High
Heart Disease 7 71.16 Quite High
Cerebrovascular Disease 14 69.12 Quite High
Disease 77 62.88 Quite High
Diarrhoea 7 62.08 Quite High
Peripheral Neuropathy 21 61.28 Quite High
Renal Failure 7 53.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that in all the tissues tested, maximum GL-3 reduction can be obtained using a combination of ERT plus SRT, and that within this context, more frequent dosing with enzyme appears to be more effective.


Negative_regulation (reduction) of GL-3
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Relative efficacy of SRT and ERT at reducing GL-3 levels in Fabry mouse tissues differed with SRT being more effective in the kidney, and ERT more efficacious in the heart and liver.
Negative_regulation (reducing) of GL-3 in liver
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2991350 Disease Relevance 0.51 Pain Relevance 0
We went on to demonstrate that the most effective treatment at reducing the levels of GL-3 was by combining ERT every two months with SRT.
Negative_regulation (reducing) of GL-3
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.25 Pain Relevance 0
Figure 2C depicts the total GL-3 excreted over 24 h, showing that although SRT significantly decreased urine GL-3 (?
Negative_regulation (depicts) of GL-3 in urine
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.22 Pain Relevance 0
This can be achieved by inhibiting the enzyme glucosylceramide synthase which catalyzes the first step in the synthesis of glycosphingolipids (GL-1) and therefore subsequent molecules including GL-3.
Negative_regulation (inhibiting) of GL-3
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.76 Pain Relevance 0.03
In any case, excreted uromodulin may be reflecting GL-3 buildup in the distal tubules, and these changes can be normalized most effectively in the mouse model by a combined ERT plus SRT approach.


Negative_regulation (reflecting) of GL-3 in tubules
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Relative efficacy of SRT and ERT at reducing GL-3 levels in Fabry mouse tissues differed with SRT being more effective in the kidney, and ERT more efficacious in the heart and liver.
Negative_regulation (reducing) of GL-3 in heart
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2991350 Disease Relevance 0.51 Pain Relevance 0

General Comments

This test has worked.

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