INT346576

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Sh3gl3) endosome (Sh3gl3) cytoplasm (Sh3gl3)
Anatomy Link Frequency
heart 5
urine 4
kidney 3
liver 1
spleen 1
Sh3gl3 (Mus musculus)
Pain Link Frequency Relevance Heat
hypoalgesia 7 20.36 Low Low
peripheral neuropathy 21 5.00 Very Low Very Low Very Low
Spinal cord 14 5.00 Very Low Very Low Very Low
Neuropathic pain 14 5.00 Very Low Very Low Very Low
Peripheral nervous system 14 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
analgesia 7 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Proteinuria 7 99.84 Very High Very High Very High
Renal Disease 7 93.12 High High
Chronic Renal Failure 7 90.56 High High
Disease 77 89.40 High High
Death 7 88.00 High High
Polyuria 7 83.52 Quite High
Renal Failure 7 80.00 Quite High
Renal Insufficiency 7 73.08 Quite High
Hypoalagesia 7 20.36 Low Low
Fabry Disease 126 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Visceral tissues (liver, kidney, heart and spleen), whole blood and urine all demonstrated elevated levels of GL-3 in the Fabry-Rag mouse relative to the wild-type controls at all time points (data not shown).
Positive_regulation (elevated) of Gene_expression (levels) of GL-3 in heart
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
SRT normalizes urine volume and decreases urine GL-3 levels
Positive_regulation (urine) of Gene_expression (levels) of GL-3 in urine
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.60 Pain Relevance 0
In untreated Fabry patients, GL-3 deposition in the kidney leads to proteinuria and progressively decreasing glomerular filtration rates.
Positive_regulation (leads) of Gene_expression (deposition) of GL-3 in kidney associated with proteinuria
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.64 Pain Relevance 0
20-fold increase in urine GL-3 levels in the untreated Fabry mice relative to that of age-matched wild-type controls.
Positive_regulation (increase) of Gene_expression (levels) of GL-3 in urine
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0.63 Pain Relevance 0
Visceral tissues (liver, kidney, heart and spleen), whole blood and urine all demonstrated elevated levels of GL-3 in the Fabry-Rag mouse relative to the wild-type controls at all time points (data not shown).
Positive_regulation (elevated) of in kidney Gene_expression (levels) of GL-3 in heart
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Visceral tissues (liver, kidney, heart and spleen), whole blood and urine all demonstrated elevated levels of GL-3 in the Fabry-Rag mouse relative to the wild-type controls at all time points (data not shown).
Positive_regulation (elevated) of in liver Gene_expression (levels) of GL-3 in heart
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0
Visceral tissues (liver, kidney, heart and spleen), whole blood and urine all demonstrated elevated levels of GL-3 in the Fabry-Rag mouse relative to the wild-type controls at all time points (data not shown).
Positive_regulation (elevated) of in spleen Gene_expression (levels) of GL-3 in heart
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991350 Disease Relevance 0 Pain Relevance 0

General Comments

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