INT3466
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Low levels of EP receptor expression were found in neurofilament-immunostained axons, but no consistent differences were observed in the levels of axonal EP staining between CCI and control tissue. | |||||||||||||||
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Immunohistochemistry was used to examine the expression of prostaglandin E(2) receptors EP1 and EP4 in sciatic nerves from the rat chronic constriction injury (CCI) model of neuropathic pain. | |||||||||||||||
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The results of this study suggested that spinal PGE2 activates the EP1 receptors existing on the central terminals of primary afferents, subsequently increasing in [Ca2+]i in the spinal dorsal horn, which are involved in the mechanisms of spinal PGE2-induced nociceptive transmission. | |||||||||||||||
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In this study, we examined whether overproduced PGs alter the expression of PGE2 receptors, EP1-EP4, in injured nerve of PSNL rats. | |||||||||||||||
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About 48% of macrophages expressed EP1 and 45% expressed EP4. | |||||||||||||||
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Moreover, in situ hybridization revealed EP1 hybridization signals in the DRG neurons, but not in the spinal cord. | |||||||||||||||
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About 48% of macrophages expressed EP1 and 45% expressed EP4. | |||||||||||||||
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The possible mechanism(s) that induce an increment in PGE1 generation accompanied by a simultaneous decrement of PGE2 during hypoxia is discussed in connection with a possible role of PGE1 evoking uterine contractions when the gassing of the suspending solution is stopped. | |||||||||||||||
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The highest increase in fluorescence intensity was obtained with electroporation-assisted gene delivery using EP1 in the present study. | |||||||||||||||
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Prostaglandin E1 is excreted by the kidneys, and elimination is almost complete within 24 hours after administration; 80 percent of it is rapidly metabolized after one pass through the pulmonary bed. | |||||||||||||||
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Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose-related antinociceptive activity. 2. | |||||||||||||||
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Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose-related antinociceptive activity. 2. | |||||||||||||||
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So far, NE-mediated regulation of EP receptor expression on microglia has not been studied. | |||||||||||||||
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In doses of 10-20 micrograms, PGE1 produces full erections in 70-80% of patients with erectile dysfunction. | |||||||||||||||
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Chemically produced prostaglandin E1 (PGE1) was administered in clinical cases of orthodontic tooth movement. | |||||||||||||||
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Chemically produced prostaglandin E1 (PGE1) was administered in clinical cases of orthodontic tooth movement. | |||||||||||||||
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They found that although EP1, 2, 3C and 4 are expressed in DRG neurons, as observed by others [54], only EP3C and EP4 receptor subtypes mediate the PGE2-induced cAMP production and increased release of substance P and CGRP. | |||||||||||||||
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DRG neurons expressing other EP receptor subtypes or devoid of EP receptor expression could contribute to the varying PGE2 actions. | |||||||||||||||
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DRG neurons expressing other EP receptor subtypes or devoid of EP receptor expression could contribute to the varying PGE2 actions. | |||||||||||||||
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PGE2 acts on four different receptors, EP1-EP4 [66], of which microglia express three, namely EP1, EP2, and EP3; the latter having been exclusively detected in activated microglia [67]. | |||||||||||||||
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General Comments
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