INT3466

Context Info Confidence 0.75 First Reported 1977 Last Reported 2010 Negated 1 Speculated 1 Reported most in Abstract Documents 39 Total Number 42 Disease Relevance 18.34 Pain Relevance 15.75

plasma membrane (Ptger1) signal transducer activity (Ptger1)

Anatomy Link Frequency PGE1 9 neurons 4 body 4 microglia 3 macrophages 2 Ptger1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Clonidine 10 99.92 dorsal root ganglion 63 99.84 Migraine 20 99.68 Sciatic nerve 8 99.52 Antinociceptive 14 99.36 Restless leg syndrome 28 98.96 Spinal cord 13 98.56 Eae 12 98.40 Inflammation 56 98.00 acular 12 97.98

Disease Link Frequency Relevance Heat Sleep Disorders 3 99.86 Ganglion Cysts 68 99.84 Nociception 39 99.84 Headache 34 99.68 Increased Venous Pressure Under Development 47 98.96 Asthma 8 98.40 Reprotox - General 2 9 98.28 INFLAMMATION 71 98.00 Hypoxia 8 97.76 Injury 19 97.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Low levels of EP receptor expression were found in neurofilament-immunostained axons, but no consistent differences were observed in the levels of axonal EP staining between CCI and control tissue.

Gene_expression (expression) of EP receptor associated with eae

1) Confidence 0.75 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17110143 Disease Relevance 0.75 Pain Relevance 0.56

Immunohistochemistry was used to examine the expression of prostaglandin E(2) receptors EP1 and EP4 in sciatic nerves from the rat chronic constriction injury (CCI) model of neuropathic pain.

Spec (examine) Gene_expression (expression) of EP1 in sciatic nerves associated with eae, injury, neuropathic pain and sciatic nerve

2) Confidence 0.75 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17110143 Disease Relevance 0.69 Pain Relevance 0.53

The results of this study suggested that spinal PGE2 activates the EP1 receptors existing on the central terminals of primary afferents, subsequently increasing in [Ca2+]i in the spinal dorsal horn, which are involved in the mechanisms of spinal PGE2-induced nociceptive transmission.

Gene_expression (existing) of EP1 in spinal associated with nociception and spinal dorsal horn

3) Confidence 0.62 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126118 Disease Relevance 0.48 Pain Relevance 0.74

In this study, we examined whether overproduced PGs alter the expression of PGE2 receptors, EP1-EP4, in injured nerve of PSNL rats.

Gene_expression (expression) of EP1 in nerve

4) Confidence 0.60 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.19 Pain Relevance 0.44

About 48% of macrophages expressed EP1 and 45% expressed EP4.

Gene_expression (expressed) of EP1 in macrophages

5) Confidence 0.60 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.31 Pain Relevance 0.53

Moreover, in situ hybridization revealed EP1 hybridization signals in the DRG neurons, but not in the spinal cord.

Gene_expression (signals) of EP1 in neurons associated with spinal cord

6) Confidence 0.48 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126118 Disease Relevance 0.46 Pain Relevance 0.80

About 48% of macrophages expressed EP1 and 45% expressed EP4.

Gene_expression (expressed) of EP1 in macrophages

7) Confidence 0.46 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.31 Pain Relevance 0.53

The possible mechanism(s) that induce an increment in PGE1 generation accompanied by a simultaneous decrement of PGE2 during hypoxia is discussed in connection with a possible role of PGE1 evoking uterine contractions when the gassing of the suspending solution is stopped.

Gene_expression (generation) of PGE1 in uterine associated with hypoxia and dismenorea

8) Confidence 0.40 Published 1981 Journal Prostaglandins Med Section Abstract Doc Link 6948305 Disease Relevance 0.74 Pain Relevance 0.12

The highest increase in fluorescence intensity was obtained with electroporation-assisted gene delivery using EP1 in the present study.

Gene_expression (using) of EP1

9) Confidence 0.40 Published 2004 Journal BMC Cancer Section Body Doc Link PMC534104 Disease Relevance 0.37 Pain Relevance 0

Prostaglandin E1 is excreted by the kidneys, and elimination is almost complete within 24 hours after administration; 80 percent of it is rapidly metabolized after one pass through the pulmonary bed.

Gene_expression (excreted) of Prostaglandin E1

10) Confidence 0.39 Published 1993 Journal Neonatal Netw Section Abstract Doc Link 8510622 Disease Relevance 0.29 Pain Relevance 0.08

Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose-related antinociceptive activity. 2.

Gene_expression (produced) of prostaglandin E1 in PGE1 associated with sleep disorders and antinociceptive

11) Confidence 0.38 Published 1977 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 891040 Disease Relevance 0.10 Pain Relevance 0.63

Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose-related antinociceptive activity. 2.

Gene_expression (produced) of PGE1 in PGE1 associated with sleep disorders and antinociceptive

12) Confidence 0.38 Published 1977 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 891040 Disease Relevance 0.10 Pain Relevance 0.63

So far, NE-mediated regulation of EP receptor expression on microglia has not been studied.

Gene_expression (expression) of EP receptor in microglia

13) Confidence 0.37 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.53 Pain Relevance 0.18

In doses of 10-20 micrograms, PGE1 produces full erections in 70-80% of patients with erectile dysfunction.

Gene_expression (produces) of PGE1 in PGE1 associated with reprotox - general 2

14) Confidence 0.36 Published 1994 Journal Clin Investig Section Abstract Doc Link 8186662 Disease Relevance 0.71 Pain Relevance 0

Chemically produced prostaglandin E1 (PGE1) was administered in clinical cases of orthodontic tooth movement.

Gene_expression (produced) of prostaglandin E1 in tooth

15) Confidence 0.36 Published 1984 Journal Am J Orthod Section Abstract Doc Link 6587784 Disease Relevance 0 Pain Relevance 0

Chemically produced prostaglandin E1 (PGE1) was administered in clinical cases of orthodontic tooth movement.

Gene_expression (produced) of PGE1 in tooth

16) Confidence 0.36 Published 1984 Journal Am J Orthod Section Abstract Doc Link 6587784 Disease Relevance 0 Pain Relevance 0

They found that although EP1, 2, 3C and 4 are expressed in DRG neurons, as observed by others [54], only EP3C and EP4 receptor subtypes mediate the PGE2-induced cAMP production and increased release of substance P and CGRP.

Gene_expression (expressed) of EP1 in neurons associated with dorsal root ganglion and substance p

17) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.25 Pain Relevance 0.34

DRG neurons expressing other EP receptor subtypes or devoid of EP receptor expression could contribute to the varying PGE2 actions.

Gene_expression (expression) of EP receptor in neurons associated with dorsal root ganglion

18) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.60 Pain Relevance 0.42

DRG neurons expressing other EP receptor subtypes or devoid of EP receptor expression could contribute to the varying PGE2 actions.

Gene_expression (expressing) of EP receptor in neurons associated with dorsal root ganglion

19) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.54 Pain Relevance 0.43

PGE2 acts on four different receptors, EP1-EP4 [66], of which microglia express three, namely EP1, EP2, and EP3; the latter having been exclusively detected in activated microglia [67].

Gene_expression (express) of EP1 in microglia

20) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0.69 Pain Relevance 0.15

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