INT34663

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Context Info
Confidence 0.68
First Reported 1988
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
large intestines 1
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 12 100.00 Very High Very High Very High
tetrodotoxin 1 87.80 High High
anesthesia 1 80.04 Quite High
nMDA receptor 1 75.00 Quite High
excitatory amino acid 1 69.12 Quite High
nMDA receptor antagonist 1 63.08 Quite High
antagonist 1 61.00 Quite High
Glutamate receptor 1 45.56 Quite Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 9 99.18 Very High Very High Very High
Necrosis 2 98.90 Very High Very High Very High
Death 1 81.40 Quite High
Shock 2 75.00 Quite High
Toxicity 2 34.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the neurotoxicity of PDC was blocked by coincubation with glutamate-pyruvate transaminase plus pyruvate to degrade extracellular glutamate.
Protein_catabolism (degrade) of glutamate-pyruvate transaminase associated with glutamate and drug induced neurotoxicity
1) Confidence 0.68 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921275 Disease Relevance 0.64 Pain Relevance 0.57
Findings unique to SA administration compared to those with Escherichia coli were the absence of significant necrosis of the mucosal intestinal glands of the small and large intestines; widespread intravascular colonization of bacteria in lung, heart, kidney and adrenal tissues often associated with neutrophil sequestration, microabscess formation, and necrosis; relative constant blood pressure, fibrinogen, fibrin degradation products (FDP), serum glutamic pyruvic transaminase (SGPT), blood (serum) urea nitrogen (BUN), creatinine, pH, and PO2, all of which remained relatively unchanged for 6 hr.
Protein_catabolism (degradation) of serum glutamic pyruvic transaminase in large intestines associated with necrosis
2) Confidence 0.50 Published 1988 Journal Circ. Shock Section Abstract Doc Link 3061682 Disease Relevance 0.35 Pain Relevance 0.08

General Comments

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