INT346683

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (URI1) protein folding (URI1) nucleus (URI1)
cytoplasm (URI1)
Anatomy Link Frequency
liver 1
URI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 2 93.04 High High
fibrosis 2 44.20 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 10 91.44 High High
Mycobacterial Infection 130 45.60 Quite Low
Cystic Fibrosis 2 44.20 Quite Low
Infection 16 43.28 Quite Low
Sprains And Strains 6 38.60 Quite Low
Disease 6 5.00 Very Low Very Low Very Low
Cough 4 5.00 Very Low Very Low Very Low
Weight Loss 4 5.00 Very Low Very Low Very Low
Fever 4 5.00 Very Low Very Low Very Low
Hot Flashes 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When methotrexate 100 nm C16G3 niosomes containing either 47.5% or 30% cholesterol were administered intravenously or orally, higher levels of the drug were found in the liver, more so for the formulations administered by the intravenous route, with serum levels higher than when the drug was administered in solution.[19] Niosomes have been used for improving the stability of entrapped drug RMP.


Protein_catabolism (stability) of RMP in liver associated with methotrexate
1) Confidence 0.19 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991688 Disease Relevance 0 Pain Relevance 0.05
-CD protects the drug, controls the release rate of the drug, and improves the stability of RMP in fixed dose combinations (FDCs).


Protein_catabolism (stability) of RMP
2) Confidence 0.19 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991688 Disease Relevance 0.15 Pain Relevance 0

General Comments

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