INT34669

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Context Info
Confidence 0.25
First Reported 1988
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 10.79
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
pancreas 1
Hypism (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 11 99.38 Very High Very High Very High
Chronic pancreatitis 4 98.92 Very High Very High Very High
tolerance 6 90.40 High High
cva 3 74.92 Quite High
opiate 2 73.76 Quite High
antagonist 1 73.20 Quite High
Inflammation 15 66.80 Quite High
Dismenorea 1 61.88 Quite High
Angina 3 27.16 Quite Low
melanocortin 1 receptor 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 141 100.00 Very High Very High Very High
Insulin Resistance 135 100.00 Very High Very High Very High
Obesity 54 100.00 Very High Very High Very High
Hyperinsulinism 31 100.00 Very High Very High Very High
Pancreatic Cancer 12 100.00 Very High Very High Very High
Hyperglycemia 9 99.60 Very High Very High Very High
Pancreatitis 4 98.92 Very High Very High Very High
Hypoglycemia 4 97.44 Very High Very High Very High
Cervical Cancer 1 95.28 Very High Very High Very High
Coronary Artery Disease 78 94.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, a key discovery of these experiments, and of particular relevance to this study, was that a very low level of ubiquitous agouti expression did not cause obesity or hyperinsulinemia, but was sufficient to promote carcinogenesis in some tissues.
Neg (not) Localization (cause) of hyperinsulinemia associated with obesity and hyperinsulinism
1) Confidence 0.25 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.06 Pain Relevance 0
Different clinical features of diabetes are associated with these two conditions: hyperinsulinemia and peripheral insulin resistance are the prevailing diabetic traits in pancreatic cancer, whereas reduced islet cell mass and impaired insulin secretion are typically observed in chronic pancreatitis.
Localization (secretion) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis
2) Confidence 0.14 Published 2008 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 18777459 Disease Relevance 1.55 Pain Relevance 0.19
Peripheral insulin resistance and hyperinsulinemia are the predominant diabetic traits in pancreatic cancer, while reduced islet cell mass and impaired insulin secretion are observed more often in chronic pancreatitis.
Localization (secretion) of hyperinsulinemia associated with diabetes mellitus, pancreatic cancer, hyperinsulinism, insulin resistance and chronic pancreatitis
3) Confidence 0.08 Published 2009 Journal Pancreatology Section Abstract Doc Link 19299909 Disease Relevance 1.67 Pain Relevance 0.19
This is accompanied by increased insulin synthesis resulting in hyperinsulinemia which is thought to be a compensatory response to reduced insulin sensitivity.
Localization (resulting) of hyperinsulinemia associated with hyperinsulinism
4) Confidence 0.07 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 1.77 Pain Relevance 0.05
CD38 autoantibodies possibly stimulate both insulin rsecretion resulting in hyperinsulinemia, the prominent
Localization (resulting) of hyperinsulinemia associated with hyperinsulinism
5) Confidence 0.06 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2656910 Disease Relevance 0.88 Pain Relevance 0
OCs increase insulin secretion and hyperinsulinemia increases the cardiovascular risk.
Localization (secretion) of hyperinsulinemia associated with hyperinsulinism
6) Confidence 0.04 Published 1993 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 8365502 Disease Relevance 1.69 Pain Relevance 0.21
Naloxone potentiated endotoxin-induced hyperinsulinemia and insulin hypersecretion from the endotoxic pancreas in fed, but not fasted, rats.
Localization (hypersecretion) of hyperinsulinemia in pancreas associated with narcan and hyperinsulinism
7) Confidence 0.03 Published 1988 Journal Circ. Shock Section Abstract Doc Link 3061683 Disease Relevance 0.34 Pain Relevance 0.56
In this study, the researchers have investigated whether markers of insulin resistance (fasting hyperinsulinemia) and of altered insulin secretion (fasting hyperglycemia, and increased glycated hemoglobin, which indicates how much sugar has been in the blood over the past few months) are associated with CHD and strokes in elderly women without diabetes.
Localization (secretion) of hyperinsulinemia in blood associated with hyperglycemia, diabetes mellitus, stroke, hyperinsulinism and insulin resistance
8) Confidence 0.01 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1952205 Disease Relevance 1.82 Pain Relevance 0

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