INT346744

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytoplasm (Dlg4, Tinagl1) extracellular region (Tinagl1) plasma membrane (Dlg4) protein complex assembly (Dlg4) response to stress (Dlg4)

Anatomy Link Frequency synapse 1 Dlg4 (Rattus norvegicus) Tinagl1 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 31 9.68 Glutamate receptor 20 5.00 antagonist 9 5.00 potassium channel 3 5.00 Hippocampus 3 5.00 Spinal cord 1 5.00 conotoxin 1 5.00 nMDA receptor 1 5.00 opioid receptor 1 5.00 Opioid 1 5.00

Disease Link Frequency Relevance Heat Disease 7 5.00 Intellectual Impairment 3 5.00 Rupture 2 5.00 Stress 2 5.00 Brain Hemorrhage 1 5.00 Limbic Encephalitis 1 5.00 Death 1 5.00 Adhesions 1 5.00 Retina Disease 1 5.00 Motor Neuron Diseases 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the synapse, the C-termini of stargazin/TARP and CKAMP44 interact with the synaptic scaffold proteins such as PSD-95 that belongs to the membrane associated guanylate kinase (MAGUK) family

PSD-95 Binding (interact) of TARP in synapse

1) Confidence 0.03 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.