INT346826

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.88
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb2) cell adhesion (Efnb2) plasma membrane (Efnb2)
Anatomy Link Frequency
nerve 2
Efnb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 80 99.52 Very High Very High Very High
nMDA receptor 32 99.52 Very High Very High Very High
Pain 76 99.40 Very High Very High Very High
Inflammation 36 99.20 Very High Very High Very High
bradykinin 4 98.68 Very High Very High Very High
Inflammatory mediators 4 98.18 Very High Very High Very High
Eae 64 94.88 High High
Spontaneous pain 4 94.56 High High
Dorsal horn 84 92.12 High High
chung model 4 87.60 High High
Disease Link Frequency Relevance Heat
Injury 20 99.56 Very High Very High Very High
Neuropathic Pain 128 99.52 Very High Very High Very High
Pain 88 99.40 Very High Very High Very High
INFLAMMATION 40 99.20 Very High Very High Very High
Targeted Disruption 268 96.88 Very High Very High Very High
Inflammatory Pain 36 94.52 High High
Hyperalgesia 40 18.16 Low Low
Nervous System Injury 12 16.08 Low Low
Nociception 24 5.00 Very Low Very Low Very Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In other cell types, for example bone, the induction of ephrin-B2 expression through the activation of transcription factor NFAT has been documented [33].
Positive_regulation (induction) of Gene_expression (expression) of ephrin-B2
1) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.88 Pain Relevance 0.86
There is also evidence that in neuropathic pain caused by nerve crush, ephrin-B2 expression is enhanced with similar consequences for synaptic signaling [10].
Positive_regulation (enhanced) of Gene_expression (expression) of ephrin-B2 in nerve associated with neuropathic pain
2) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.12 Pain Relevance 1.02
Many inflammatory mediators - for example bradykinin - are also known to induce NFAT expression, so it is likely that enhanced expression of ephrin-B2 results in NMDA receptor NR2B phosphorylation that potentiates synaptic efficacy and increase calcium flux.
Positive_regulation (enhanced) of Gene_expression (expression) of ephrin-B2 associated with inflammatory mediators, nmda receptor and bradykinin
3) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.06 Pain Relevance 1.02
The mechanism underlying the enhanced signaling mediated by ephrin-B2 in inflammation and tissue injury is likely to reflect increased ephrin-B2 protein expression in sensitized pain states.
Positive_regulation (increased) of Gene_expression (expression) of ephrin-B2 protein associated with pain, inflammation and injury
4) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.83 Pain Relevance 0.81

General Comments

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