INT346828

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 8.57
Pain Relevance 3.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Efnb2) cell adhesion (Efnb2) plasma membrane (Efnb2)
Anatomy Link Frequency
spinal cord 1
microglial cells 1
Efnb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 261 99.44 Very High Very High Very High
Thermal hyperalgesia 72 99.28 Very High Very High Very High
nMDA receptor 72 98.04 Very High Very High Very High
Sciatic nerve 63 97.88 Very High Very High Very High
allodynia 81 97.04 Very High Very High Very High
Eae 144 93.96 High High
Dorsal horn 189 92.80 High High
nociceptor 99 92.52 High High
nav1.8 135 85.56 High High
Inflammation 81 81.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 603 99.80 Very High Very High Very High
Hyperalgesia 90 99.28 Very High Very High Very High
Neuropathic Pain 288 97.04 Very High Very High Very High
Congenital Anomalies 9 95.80 Very High Very High Very High
Inflammatory Pain 81 93.96 High High
Nociception 54 90.40 High High
Nervous System Injury 27 90.24 High High
INFLAMMATION 90 81.88 Quite High
Pain 198 68.88 Quite High
Sprains And Strains 9 16.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both Efnb2 CKO mice and Efnb2fl/fl controls show the similar thermal hyperalgesia response (Figure 4D).
Regulation (controls) of Efnb2fl associated with targeted disruption and thermal hyperalgesia
1) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.70 Pain Relevance 1.00
Immunoprecipitation (IP) and Western blot of NR2B was performed to establish whether formalin treatment induces tyrosine phosphorylation of NMDA receptor subunit NR2B, and if the extent of the phosphorylation is different in Efnb2 CKO mutant mice and Efnb2fl/fl controls.
Regulation (controls) of Efnb2fl associated with targeted disruption and nmda receptor
2) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.73 Pain Relevance 0.61
They showed no obvious differences from Efnb2fl/fl controls in appearance and spontaneous behavior.
Neg (no) Regulation (controls) of Efnb2fl
3) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.90 Pain Relevance 0.09
Ten Efnb2 CKO mutant mice and ten Efnb2fl/fl controls were observed with Hargreaves and von Frey.
Regulation (controls) of Efnb2fl associated with targeted disruption
4) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.56 Pain Relevance 0.79
After partial ligation of sciatic nerve, the expression of GFAP positive cells in the ipsilateral side of spinal cord significantly increased in Efnb2fl/fl controls and Efnb2 CKO mutant mice compared to sham controls (Additional file 1, S6).
Regulation (controls) of Efnb2fl in spinal cord associated with targeted disruption, sciatic nerve and spinal cord
5) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.53 Pain Relevance 0.43
Age (8-13 weeks) -matched and sex-mixed Efnb2 CKO mutant mice (n = 9) and Efnb2fl/fl controls (n = 8) were weighed and used for von Frey, Randall Selitto, Hargreaves', hot plate and cold plate tests.
Regulation (controls) of Efnb2fl associated with targeted disruption
6) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.99 Pain Relevance 0.09
There were similar number of positvie microglial cells in sham animals (0.13 ± 0.04, Efnb2fl/fl controls; 0.02 ± 0.02, Efnb2 CKO) in 104 ?
Regulation (controls) of Efnb2fl in microglial cells associated with targeted disruption
7) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.56 Pain Relevance 0.39
There was no apparent difference between Efnb2fl/fl controls and Efnb2 CKO mutant mice.
Regulation (controls) of Efnb2fl associated with targeted disruption
8) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.72 Pain Relevance 0.22
We therefore used the exon 2 ephrin-B2 conditional knockout (Efnb2 CKO) mutant mice and their floxed exon 2 ephrin-B2 (Efnb2fl/fl) littermate controls for further experiments.


Regulation (controls) of ephrin-B2 associated with targeted disruption
9) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.88 Pain Relevance 0.19

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