INT346835

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Efnb2, Grin2b) cell differentiation (Efnb2) transport (Grin2b)
cell adhesion (Efnb2) embryo development (Grin2b)
Efnb2 (Mus musculus)
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 100.00 Very High Very High Very High
bradykinin 1 98.50 Very High Very High Very High
Inflammatory mediators 1 98.00 Very High Very High Very High
Dorsal horn 21 92.32 High High
Pain 19 88.36 High High
Eae 16 88.00 High High
Inflammation 9 84.48 Quite High
Spontaneous pain 1 80.64 Quite High
Neuropathic pain 20 78.88 Quite High
Spinal cord 29 70.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 97.80 Very High Very High Very High
Pain 22 88.36 High High
Inflammatory Pain 9 88.00 High High
Injury 5 85.20 High High
Targeted Disruption 67 82.56 Quite High
Neuropathic Pain 32 78.88 Quite High
Hyperalgesia 10 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many inflammatory mediators - for example bradykinin - are also known to induce NFAT expression, so it is likely that enhanced expression of ephrin-B2 results in NMDA receptor NR2B phosphorylation that potentiates synaptic efficacy and increase calcium flux.
Gene_expression (expression) of ephrin-B2 Positive_regulation (results) of Phosphorylation (phosphorylation) of NR2B associated with inflammatory mediators, nmda receptor and bradykinin
1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 1.07 Pain Relevance 1.03

General Comments

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