INT346895

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.74
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nod2) signal transduction (Nod2) plasma membrane (Nod2)
intracellular (Nod2) enzyme binding (Nod2) cytoplasm (Nod2)
Anatomy Link Frequency
ileum 2
Nod2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 54 94.00 High High
Crohn's disease 40 81.68 Quite High
cytokine 6 47.40 Quite Low
spastic colon 2 37.28 Quite Low
Bile 12 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 46 94.00 High High
Disease 56 81.68 Quite High
Metaplasia 6 68.48 Quite High
Infection 22 60.48 Quite High
Inflammatory Bowel Disease 40 57.08 Quite High
Targeted Disruption 12 46.84 Quite Low
Sprains And Strains 6 39.60 Quite Low
Functional Bowel Disorder 2 37.28 Quite Low
Colitis 4 25.52 Quite Low
Bacterial Respiratory Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corroborating the concept of a host driven composition of the microbial flora, Petnicki-Ocweija et al. showed that in the mouse model, the bactericidal activity of crypt secretions of the terminal ileum was severely compromised by NOD2 deletion, and that NOD2 expression depends on the presence of commensal bacteria [50].
Positive_regulation (depends) of Gene_expression (expression) of NOD2 in ileum
1) Confidence 0.33 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.13 Pain Relevance 0.04
Further investigations revealed that 1,25-dihydroxyvitamin D3 and MDP induce expression of hBD-2 and cathelicidin through stimulation of NOD2 expression [88].
Positive_regulation (stimulation) of Gene_expression (expression) of NOD2
2) Confidence 0.31 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.61 Pain Relevance 0.24

General Comments

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