INT346904

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.58 Pain Relevance 0

extracellular space (DEFA5) extracellular region (DEFA5)

DEFA5 (Homo sapiens)

Pain Link Frequency Relevance Heat Bile 6 43.00 Inflammation 27 38.12 Crohn's disease 20 5.00 cytokine 3 5.00 chemokine 3 5.00 Inflammatory response 2 5.00 corticosteroid 1 5.00 spastic colon 1 5.00 iatrogenic 1 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Infection 11 95.56 Targeted Disruption 6 94.28 Colitis 2 90.52 INFLAMMATION 23 38.12 Inflammatory Bowel Disease 20 29.64 Disease 28 5.00 Bacterial Respiratory Disease 7 5.00 Gastritis 4 5.00 Metaplasia 3 5.00 Sprains And Strains 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interesting in this context is the fact that S. typhimurium can downregulate HD-5 expression via a type-3 secretion system (see Figure 1).

Negative_regulation (downregulate) of Gene_expression (expression) of HD-5

1) Confidence 0.03 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2992817 Disease Relevance 0.58 Pain Relevance 0

General Comments

This test has worked.