INT346914

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Context Info
Confidence 0.05
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Kars, Car2) cytosol (Car2) extracellular space (Car2)
mitochondrion (Kars) lyase activity (Car2) translation (Kars)
Anatomy Link Frequency
neuronal 3
Kars (Mus musculus)
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 15 94.64 High High
agonist 4 87.20 High High
Glutamate receptor 4 85.36 High High
Central nervous system 16 73.28 Quite High
Multiple sclerosis 4 56.88 Quite High
nMDA receptor 3 44.48 Quite Low
Hippocampus 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 6 98.44 Very High Very High Very High
Neurodegenerative Disease 27 96.96 Very High Very High Very High
Necrosis 2 96.04 Very High Very High Very High
Helminth Infection 1 91.04 High High
Death 27 69.12 Quite High
Convulsion 18 68.48 Quite High
Multiple Sclerosis 7 56.88 Quite High
Motor Neuron Diseases 1 55.52 Quite High
Disease 8 53.28 Quite High
INFLAMMATION 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon binding to KARs, KA induces a number of cellular events, including the influx of cellular Ca2+, production of reactive oxygen species (ROS), and mitochondrial dysfunction leading to neuronal apoptosis and necrosis [2].
KARs Binding (binding) of in neuronal Positive_regulation (induces) of Gene_expression (production) of Ca2 in neuronal associated with parkinson's disease, necrosis and neurodegenerative disease
1) Confidence 0.05 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 1.24 Pain Relevance 0.45

General Comments

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