INT34693

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Context Info
Confidence 0.47
First Reported 1982
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 3.03

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Anatomy Mention Frequency
brain 2


Pain Term Frequency Confidence Heat
narcan 5 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Morphine 26 99.66 Very High Very High Very High
Analgesic 5 94.32 High High
opioid receptor 1 88.16 High High
Potency 2 87.44 High High
opiate 1 79.12 Quite High
Opioid 1 75.00 Quite High
addiction 2 68.80 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of AcS-morphine on the specific binding of [3H]-naloxone, [3H]-ethylketocyclazocine and [3H]-D-Ala2-D-Leu5-enkephalin to the membrane fractions from the rat brain were tested.
Leu5 Binding (binding) of in brain associated with narcan, enkephalin and morphine
1) Confidence 0.47 Published 1988 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3069065 Disease Relevance 0 Pain Relevance 2.29
The interaction of metkephamid (Tyr-D-Ala-Gly-Phe-N(Me)Met-NH2) with 3H-dihydromorphine and 3H-D-Ala2-D-Leu5-enkephalin binding has been examined in rat brain homogenates.
Leu5 Binding (binding) of in brain associated with enkephalin
2) Confidence 0.47 Published 1982 Journal Peptides Section Abstract Doc Link 6294639 Disease Relevance 0 Pain Relevance 0.74

General Comments

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