INT346939

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nose 2
polymerase (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 93.68 High High
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 20 96.92 Very High Very High Very High
INFLAMMATION 5 93.68 High High
Sprains And Strains 21 53.36 Quite High
Infection 10 5.00 Very Low Very Low Very Low
Fever 2 5.00 Very Low Very Low Very Low
Respiratory Syncytial Virus 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, a single mutation, PB2 D87N, was responsible for increased G2 RNP polymerase activity at the lower temperature (33°C) found in the mammalian airway and, therefore, probably contributed to better replication in the nose, significantly elevated inflammation, or more efficient transmission.
Positive_regulation (increased) of Gene_expression (activity) of polymerase in nose associated with inflammation
1) Confidence 0.04 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.32 Pain Relevance 0.05

General Comments

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