INT346968

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.21
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)
Anatomy Link Frequency
neural 2
HDAC9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 74.60 Quite High
Inflammation 25 70.92 Quite High
fibrosis 1 23.04 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 84.36 Quite High
INFLAMMATION 26 70.92 Quite High
Stress 3 58.24 Quite High
Toxicity 20 50.00 Quite Low
Bronchiectasis 1 24.96 Low Low
Pulmonary Fibrosis 1 23.04 Low Low
Bronchitis 2 16.24 Low Low
Asthma 3 15.32 Low Low
Pulmonary Disease 11 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, melatonin significantly increased mRNA expression for various HDAC isoforms and increased histone H3 acetylation in neural stem cell lines.


Positive_regulation (increased) of Transcription (expression) of HDAC in neural
1) Confidence 0.22 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.21 Pain Relevance 0.07

General Comments

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