INT346968

Context Info Confidence 0.22 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.21 Pain Relevance 0.07

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)

Anatomy Link Frequency neural 2 HDAC9 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 3 74.60 Inflammation 25 70.92 fibrosis 1 23.04 cytokine 4 5.00 Paracetamol 2 5.00 Inflammatory response 2 5.00 chemokine 1 5.00

Disease Link Frequency Relevance Heat Cancer 4 84.36 INFLAMMATION 26 70.92 Stress 3 58.24 Toxicity 20 50.00 Bronchiectasis 1 24.96 Pulmonary Fibrosis 1 23.04 Bronchitis 2 16.24 Asthma 3 15.32 Pulmonary Disease 11 5.00 Disease 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, melatonin significantly increased mRNA expression for various HDAC isoforms and increased histone H3 acetylation in neural stem cell lines.

Positive_regulation (increased) of Transcription (expression) of HDAC in neural

1) Confidence 0.22 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 0.21 Pain Relevance 0.07

General Comments

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