INT34704

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.17
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
plasma 2
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Neuropeptide 4 98.94 Very High Very High Very High
qutenza 3 93.68 High High
bradykinin 1 86.92 High High
narcan 1 84.84 Quite High
opioid receptor 1 83.20 Quite High
Endogenous opioid 1 79.44 Quite High
Intracerebroventricular 1 61.60 Quite High
c fibre 1 43.88 Quite Low
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypertension 76 97.94 Very High Very High Very High
Hyperinsulinism 1 39.04 Quite Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, inhibition of central enkephalinase A by i.c.v. administration of thiorphan potentiates the pressor response to i.c.v.
Positive_regulation (potentiates) of Negative_regulation (inhibition) of enkephalinase
1) Confidence 0.47 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6360696 Disease Relevance 0.07 Pain Relevance 0.37
An alteration of the character of the P3' amino acid valine in propioxatin A, e.g. amidation of carboxylic acid or replacement of the side chain, caused a 2 to 400-fold decrease of the inhibitory activity for enkephalinase B or an appearance of enkephalinase A inhibition with Ki values in the micromolar range.
Positive_regulation (caused) of Negative_regulation (decrease) of enkephalinase
2) Confidence 0.38 Published 1988 Journal J. Biochem. Section Abstract Doc Link 3069842 Disease Relevance 0 Pain Relevance 0.07
An alteration of the character of the P3' amino acid valine in propioxatin A, e.g. amidation of carboxylic acid or replacement of the side chain, caused a 2 to 400-fold decrease of the inhibitory activity for enkephalinase B or an appearance of enkephalinase A inhibition with Ki values in the micromolar range.
Positive_regulation (appearance) of Negative_regulation (inhibition) of enkephalinase
3) Confidence 0.38 Published 1988 Journal J. Biochem. Section Abstract Doc Link 3069842 Disease Relevance 0 Pain Relevance 0.07
Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats.
Positive_regulation (Increase) of Negative_regulation (inhibitor) of enkephalinase in plasma associated with enkephalin
4) Confidence 0.28 Published 2010 Journal Horm. Metab. Res. Section Title Doc Link 20143290 Disease Relevance 0 Pain Relevance 0.26
Medium was collected after exposing the WKY and SHR cells for 60 min at 37°C under two different enzyme inhibitors conditions (+All RAS inhibitors versus minus ACE/NEP/ACE2/chymase inhibitor only) and were analyzed by HPLC as described above.
Positive_regulation (minus) of Negative_regulation (inhibitor) of NEP associated with hypertension
5) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.10 Pain Relevance 0
We conclude that sensory neuropeptides may have a protective role in modulation of airways NEP activity downregulation induced by CS, probably by preventing CS from entering the lower airways or the chronic release of sensory neuropeptides induced by CS providing increased amount of substrata for NEP upregulation, and therefore modify the direct effect of CS on NEP activity and related airway hyperresponsiveness.
Positive_regulation (induced) of Negative_regulation (downregulation) of NEP associated with neuropeptide
6) Confidence 0.13 Published 1995 Journal Life Sci. Section Abstract Doc Link 7475970 Disease Relevance 0 Pain Relevance 0.39

General Comments

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