INT34720

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Context Info
Confidence 0.69
First Reported 1974
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 58
Total Number 58
Disease Relevance 32.40
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
blood 4
plasma 2
thyroid 2
pituitary 2
tunica albuginea 1
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 144 100.00 Very High Very High Very High
carbamazepine 57 99.54 Very High Very High Very High
noradrenaline 38 99.16 Very High Very High Very High
Bioavailability 4 98.96 Very High Very High Very High
Dopamine 108 98.16 Very High Very High Very High
addiction 12 97.88 Very High Very High Very High
cocaine 4 96.84 Very High Very High Very High
headache 74 96.60 Very High Very High Very High
Catecholamine 15 93.12 High High
cva 14 92.84 High High
Disease Link Frequency Relevance Heat
Hypertension 360 100.00 Very High Very High Very High
Diabetes Mellitus 221 100.00 Very High Very High Very High
Depression 191 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 76 100.00 Very High Very High Very High
Heart Disease 13 100.00 Very High Very High Very High
Obesity 256 99.76 Very High Very High Very High
Weight Loss 45 99.72 Very High Very High Very High
Aging 179 99.68 Very High Very High Very High
Hepatotoxicity 15 99.60 Very High Very High Very High
Disease 135 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in the second category which may occur affect the adrenal glands, hypothalamus, the thyroid (increased thyroid-binding globulin), and pancreas (alterations in glucose metabolism).
Positive_regulation (increased) of thyroid-binding globulin in thyroid
1) Confidence 0.69 Published 1974 Journal Clin Obstet Gynecol Section Abstract Doc Link 4596680 Disease Relevance 1.18 Pain Relevance 0.19
Although consistent increases in SBP and DBP were observed in patients after baseline, these differences were not significant.
Positive_regulation (increases) of SBP
2) Confidence 0.67 Published 2004 Journal J. Urol. Section Body Doc Link 15201780 Disease Relevance 0.05 Pain Relevance 0
CONCLUSIONS: Although none of the 15 participants who were at risk for developing AD developed symptoms consistent with this diagnosis, 3 displayed an acute elevation in SBP, suggesting a pattern of imminent AD.
Positive_regulation (elevation) of SBP
3) Confidence 0.67 Published 2000 Journal Arch Phys Med Rehabil Section Body Doc Link 11083354 Disease Relevance 0.17 Pain Relevance 0
Peak SBP, DBP, and MBP were increased with ESM versus COMB, and peak DBP with ESM versus NIC.
Positive_regulation (increased) of SBP
4) Confidence 0.67 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10648307 Disease Relevance 0.70 Pain Relevance 0.16
Smaller increases in SBP, DBP, and HR were seen in all groups after skin incision and sternotomy.
Positive_regulation (increases) of SBP in skin
5) Confidence 0.67 Published 1985 Journal Anesthesiology Section Abstract Doc Link 3159311 Disease Relevance 0.09 Pain Relevance 0.26
The orotracheal intubation caused significant increases in SBP, DBP, MAP, and RPP in these two groups in comparision with postinduction values (P < 0.05), but these hemodynamic changes lasted only 1 to 2 minutes and then decreased gradually to the postinduction level.
Positive_regulation (increases) of SBP
6) Confidence 0.67 Published 2007 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 18051724 Disease Relevance 0 Pain Relevance 0
The reduction in free and bioavailable testosterone levels is larger because aging is also associated with increases in SHBG levels (Feldman et al 2002).
Positive_regulation (increases) of SHBG associated with aging
7) Confidence 0.60 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.01 Pain Relevance 0
Both free or bioavailable testosterone and estradiol levels decline with age due to increased serum sex-hormone binding globulin (SHBG) levels and failure of the hypothalamic-pituitary-testicular axis to compensate (Khosla et al 1998;Orwoll et al 2006).
Positive_regulation (increased) of serum sex-hormone binding globulin in pituitary
8) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.54 Pain Relevance 0
Both free or bioavailable testosterone and estradiol levels decline with age due to increased serum sex-hormone binding globulin (SHBG) levels and failure of the hypothalamic-pituitary-testicular axis to compensate (Khosla et al 1998;Orwoll et al 2006).
Positive_regulation (increased) of SHBG in pituitary
9) Confidence 0.57 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.54 Pain Relevance 0
Loss of significant weight has been reported to result in spontaneous resumption of ovulation (Crosignani et al 2003), improvement in fertility (Norman et al 2004), increased SHBG, and reduced basal level of insulin (Huber-Buchholz et al 1999; Tolino et al 2005).
Positive_regulation (increased) of SHBG
10) Confidence 0.56 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.53 Pain Relevance 0.04
It also increases sex hormone binding globulin (SHBG) which reduces FT[43].
Positive_regulation (increases) of SHBG
11) Confidence 0.56 Published 2008 Journal Cardiovasc Diabetol Section Body Doc Link PMC2576082 Disease Relevance 0.47 Pain Relevance 0
Sex hormone-binding globulin levels were elevated at baseline and decreased modestly with treatment (P < .05 vs. baseline at 5 mg/day; P < .01 vs. baseline at 7.5 mg/day).
Positive_regulation (elevated) of Sex hormone-binding globulin
12) Confidence 0.55 Published 2006 Journal J Pain Section Abstract Doc Link 16516826 Disease Relevance 0.22 Pain Relevance 0.25
Muller and colleagues suggest that low endogenous total testosterone and SHBG levels increase the risk of metabolic syndrome in aging and aged men.
Positive_regulation (increase) of SHBG associated with aging and metabolic syndrome
13) Confidence 0.52 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 1.25 Pain Relevance 0
Factors such as lack of ability, poor sex education, and psychological conflicts play an important role in the development of sexual dysfunction at the start of sexual activity.1,2 Life habits and morbid conditions become important risk factors for sexual dysfunction during aging; these factors include hypertension, diabetes, depression, heart disease, sex hormone deficiency, smoking, sedentary life style, and drug addiction.3 Socioeconomic factors, such as education, employment and marital status, have also been related to sexual difficulties.4
Positive_regulation (include) of sex hormone in heart associated with drug dependence, nicotine addiction, aging, depression, diabetes mellitus, addiction, reprotox - general 2, heart disease and hypertension
14) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882546 Disease Relevance 1.77 Pain Relevance 0.17
In addition, AEDs can decrease the availability of androgen substrates for aromatase pathway by increasing the catabolism of sex steroids and increasing SHBG levels, resulting in reduced free testosterone and DHEA levels [61-64].
Positive_regulation (increasing) of SHBG
15) Confidence 0.49 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.22 Pain Relevance 0.04
It also increases sex hormone binding globulin (SHBG) which reduces FT[43].
Positive_regulation (increases) of hormone binding globulin
16) Confidence 0.48 Published 2008 Journal Cardiovasc Diabetol Section Body Doc Link PMC2576082 Disease Relevance 0.47 Pain Relevance 0
Tibolone lowers sex hormone-binding globulin (SHBG) and increases circulating free testosterone, adding to its androgenicity.
Positive_regulation (increases) of SHBG
17) Confidence 0.45 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971736 Disease Relevance 0.67 Pain Relevance 0.03
In a crossover design involving eight women with NCAH, oral contraceptive therapy was associated with increased SHBG and decreased free testosterone concentrations.
Positive_regulation (increased) of SHBG associated with adrenal cancer
18) Confidence 0.43 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.94 Pain Relevance 0.04
If the serum total testosterone level is between 230 and 350 ng/dL in males under 50 years or between 300 and 500 ng/dL in older males, repeating the measurement of total testosterone with sex hormone binding globulin (SHBG) to calculate free testosterone or measuring free testosterone by equilibrium dialysis or bioavailable testosterone is recommended.45 Note that SHBG is elevated in elderly patients and effected by many diseases.30 Measurements of serum LH will assist in differentiating between primary and secondary hypogonadism and serum prolactin is indicated when the serum testosterone is lower than 150 ng/dl46–49 or when secondary hypogonadism is suspected.50,51 Measurement of free or bioavailable testosterone (BT, free plus albumin bound) should be considered when the serum total testosterone concentration is not diagnostic of hypogonadism, particularly in obese men.
Positive_regulation (elevated) of SHBG associated with hypogonadotropic hypogonadism, obesity and disease
19) Confidence 0.42 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 0.69 Pain Relevance 0
In cross-sectional and longitudinal studies of men aged 30 or 40 years and above, total, bioavailable and free testosterone concentrations fall with increasing age with a steeper decline in bioavailable and free compared with total testosterone concentrations.4,14,15 In older men above the age of 65 or 70 years, the changes in total testosterone are overshadowed by a more significant decline in free testosterone levels.16,17 This is a consequence of the age-associated increase of the levels of sex hormone binding globulin (SHBG) demonstrated by cross-sectional studies, and has now been confirmed by longitudinal studies.18,19 Although the fall is gradual, by the eighth decade, according to the Baltimore Longitudinal Study, 30% of men had total testosterone values in the hypogonadal range, and 50% had low free testosterone values.
Positive_regulation (increase) of SHBG
20) Confidence 0.42 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 0.29 Pain Relevance 0

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