INT347211

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 7.36
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
endothelial cells 6
cleavage 2
Icam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 28 92.20 High High
Angina 52 42.96 Quite Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 40 99.54 Very High Very High Very High
Atherosclerosis 32 97.62 Very High Very High Very High
INFLAMMATION 28 92.20 High High
Cardiovascular Disease 36 80.80 Quite High
Thrombosis 8 74.60 Quite High
Disease 12 72.96 Quite High
Hyperlipidemia 12 64.44 Quite High
Death 4 62.52 Quite High
Coronary Heart Disease 140 60.32 Quite High
Myocardial Infarction 72 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main mechanism responsible for release of sICAM-1 is believed to be proteolytic cleavage of ICAM-1 from cell membranes.3 The ICAM-1 gene is located on chromosome 19 p13.2-p13.3.
Regulation (responsible) of Localization (release) of sICAM-1 in cleavage
1) Confidence 0.54 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.85 Pain Relevance 0.19
The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intracellular adhesion molecule-1 (ICAM-1).2 Soluble ICAM-1 (sICAM-1) is a circulating form of ICAM-1 and has been shown to reflect cell surface expression of ICAM-1 in human vascular endothelial cells.
Regulation (circulating) of Localization (form) of ICAM-1 in endothelial cells associated with atherosclerosis and adhesions
2) Confidence 0.45 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.83 Pain Relevance 0.20
The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intracellular adhesion molecule-1 (ICAM-1).2 Soluble ICAM-1 (sICAM-1) is a circulating form of ICAM-1 and has been shown to reflect cell surface expression of ICAM-1 in human vascular endothelial cells.
Regulation (circulating) of Localization (form) of Soluble ICAM-1 in endothelial cells associated with atherosclerosis and adhesions
3) Confidence 0.39 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.85 Pain Relevance 0.20
The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by intracellular adhesion molecule-1 (ICAM-1).2 Soluble ICAM-1 (sICAM-1) is a circulating form of ICAM-1 and has been shown to reflect cell surface expression of ICAM-1 in human vascular endothelial cells.
Regulation (circulating) of Localization (form) of sICAM-1 in endothelial cells associated with atherosclerosis and adhesions
4) Confidence 0.39 Published 2010 Journal Annals of Saudi Medicine Section Body Doc Link PMC2994157 Disease Relevance 1.83 Pain Relevance 0.20

General Comments

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