INT347226

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Hck, Lyn) cytoplasm (Hck, Lyn) nucleus (Hck, Lyn)
plasma membrane (Hck, Lyn) kinase activity (Hck, Lyn) enzyme binding (Lyn)
Hck (Mus musculus)
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 14 75.84 Quite High
Chronic Myeloid Leukemia 3 50.00 Quite Low
Philadelphia Chromosome 12 32.60 Quite Low
Chromosome Aberrations 4 32.36 Quite Low
Myeloid Leukemia 39 23.60 Low Low
Blast Crisis 7 5.00 Very Low Very Low Very Low
Thrombocytopenia 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Neutropenia 5 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several mechanisms may contribute to imatinib resistance, including increased expression of BCR-ABL kinase through gene amplification, decreased intracellular drug concentrations caused by drug efflux proteins (OCT1), clonal evolution, or over-expression of Src kinases (Lyn, Hck) involved in BCR-ABL independent activation of alternative pathways (Apperley 2007).
Hck Regulation (involved) of Gene_expression (expression) of Lyn
1) Confidence 0.10 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.08 Pain Relevance 0

General Comments

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