INT34723

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.26
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mbl1) extracellular region (Mbl1)
Anatomy Link Frequency
plasma 2
Mbl1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 165 99.40 Very High Very High Very High
Inflammation 24 84.92 Quite High
ischemia 3 81.04 Quite High
Arthritis 45 61.12 Quite High
tolerance 1 25.00 Low Low
Pain 1 25.00 Low Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 165 99.40 Very High Very High Very High
Disease 87 98.68 Very High Very High Very High
Bone Disease 2 94.52 High High
Coronary Artery Disease 6 94.40 High High
INFLAMMATION 21 84.92 Quite High
Reperfusion Injury 3 80.32 Quite High
Diabetes Mellitus 3 78.48 Quite High
Infection 18 75.80 Quite High
Apoptosis 3 68.80 Quite High
Rheumatic Diseases 6 62.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Six single nucleotide polymorphisms (SNPs) in the MBL2 gene on chromosome 10 are known to influence MBL plasma levels.
Regulation (influence) of MBL in plasma
1) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.58 Pain Relevance 0.22
In addition, MBL plasma concentrations fluctuate in the presence or absence of three SNPs (position -550: H and L alleles; position -221: X and Y alleles; and position +4: P and Q alleles) in the promoter region of the MBL2 gene [12,13].
Regulation (fluctuate) of MBL in plasma
2) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 0.17 Pain Relevance 0.06
Harmful effects of high MBL levels have been shown in other disease entities as well.
Regulation (effects) of MBL associated with disease
3) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453777 Disease Relevance 1.34 Pain Relevance 0.36
(Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineralization was only observed at high doses.
Regulation (affect) of CIPsMBP
4) Confidence 0.00 Published 1988 Journal Bone Section Abstract Doc Link 3073800 Disease Relevance 0.17 Pain Relevance 0

General Comments

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