INT34729

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Context Info
Confidence 0.67
First Reported 1988
Last Reported 2011
Negated 11
Speculated 2
Reported most in Body
Documents 233
Total Number 235
Disease Relevance 128.04
Pain Relevance 30.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 13
plasma 6
NK cells 5
macrophages 4
monocytes 3
IFN1@ (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3973 100.00 Very High Very High Very High
Inflammation 2041 100.00 Very High Very High Very High
chemokine 381 100.00 Very High Very High Very High
spinal inflammation 143 99.28 Very High Very High Very High
rheumatoid arthritis 281 99.20 Very High Very High Very High
fibrosis 168 99.20 Very High Very High Very High
Acupuncture 56 99.12 Very High Very High Very High
Arthritis 740 98.86 Very High Very High Very High
isoflurane 51 98.84 Very High Very High Very High
tolerance 151 98.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2251 100.00 Very High Very High Very High
Immunization 853 99.98 Very High Very High Very High
Death 276 99.98 Very High Very High Very High
Mycobacterial Infection 776 99.96 Very High Very High Very High
Hepatotoxicity 15 99.92 Very High Very High Very High
Weight Gain 7 99.90 Very High Very High Very High
Infection 1961 99.82 Very High Very High Very High
Cancer 1800 99.72 Very High Very High Very High
Dengue Hemorrhagic Fever 364 99.72 Very High Very High Very High
Colitis 187 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, PspA peptides 21 and 22 mounted comparatively high proliferation responses, 20 and 21 induced consistently high IFN-?
Positive_regulation (induced) of IFN
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.40 Pain Relevance 0.04
These results indicated that monocytes increased IFN-?
Positive_regulation (increased) of IFN in monocytes
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0 Pain Relevance 0
and IL-6 secretion, we could demonstrate a direct correlation between decreased IL-6 and increased IFN-?
Positive_regulation (increased) of IFN
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.63 Pain Relevance 0.03
Enhancement of IFN-?
Positive_regulation (Enhancement) of IFN
4) Confidence 0.67 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.08 Pain Relevance 0
With the onset of chemotherapy and cure with sodium antimony gluconate (SAG) and AmB, upregulation of IFN-?
Positive_regulation (upregulation) of IFN
5) Confidence 0.67 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.36 Pain Relevance 0.08
Therefore, two or more fold upregulation of IFN-?
Positive_regulation (upregulation) of IFN
6) Confidence 0.67 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.35 Pain Relevance 0.14
This hypothesis is consistent with our findings that splenectomy strongly inhibited (i) the BDL-induced increase in ROS generation by the circulating neutrophils (Fig. 7), (ii) the elevation of plasma IFN-?
Positive_regulation (elevation) of IFN in plasma
7) Confidence 0.67 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.54 Pain Relevance 0.20
However, the highest increase in IFN-?
Positive_regulation (increase) of IFN
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0 Pain Relevance 0
NP Class II peptide-stimulated LN cultures showed a greater increase in IFN-?
Positive_regulation (increase) of IFN
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.12 Pain Relevance 0
might induce an increase of IFN-?
Positive_regulation (increase) of IFN
10) Confidence 0.67 Published 2008 Journal Arch Dermatol Res Section Body Doc Link PMC2254657 Disease Relevance 1.09 Pain Relevance 0.27
In fact, an increase of IFN-?
Positive_regulation (increase) of IFN
11) Confidence 0.67 Published 2008 Journal Arch Dermatol Res Section Body Doc Link PMC2254657 Disease Relevance 1.28 Pain Relevance 0.29
A significant downregulation of IL-12 and IL-10 in the plasma, elevation of IFN-?
Positive_regulation (elevation) of IFN in plasma
12) Confidence 0.67 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.19 Pain Relevance 0.05
In this patient, vaccinations using autologous glioma as the antigen source induced a specific IFN-?
Positive_regulation (induced) of IFN associated with glioma
13) Confidence 0.67 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.35 Pain Relevance 0
Successfully cured patients showed reduced IL-12 and IL-10 levels in the plasma and two-fold or more increase in Th1 type-cytokines IFN-?
Positive_regulation (increase) of IFN in plasma associated with cytokine
14) Confidence 0.67 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.71 Pain Relevance 0.17
Increased induction of IFN- ?
Positive_regulation (induction) of IFN
15) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.36 Pain Relevance 0.07
In contrast, co-cultures of cancer stem cells with NK cells demonstrated increased IFN-?
Positive_regulation (increased) of IFN in NK cells associated with cancer
16) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.57 Pain Relevance 0.03
In contrast, higher induction of IFN-?
Positive_regulation (induction) of IFN
17) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.26 Pain Relevance 0
On the other hand, histologic examinations of CU patients have demonstrated perivascular infiltrations of mixed Th1/ Th2 cells, eosinophils, and increased IL-4, IL-5, and IFN-?
Positive_regulation (increased) of IFN in eosinophils associated with urticaria
18) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 1.50 Pain Relevance 0.15
in cases than in controls, as elevated IFN?
Positive_regulation (elevated) of IFN
19) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2841649 Disease Relevance 1.15 Pain Relevance 0.25
Macrophages of apoE-deficient mice stimulated by exogenous antigen are more effective in the upregulating of main histocompatibility complex (MHC) class II molecules and costimulatory molecules like CD40 and CD80, with increased IFN-?
Positive_regulation (increased) of IFN in Macrophages
20) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.25 Pain Relevance 0.07

General Comments

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