INT347301

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0.16

extracellular space (CCL16) extracellular region (CCL16) cell-cell signaling (CCL16)

Anatomy Link Frequency lens capsule 1 AREG (Homo sapiens) CCL16 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 1 96.20 diclofenac 2 59.60 cINOD 1 56.32 cytokine 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Death 3 99.96 Capsule Opacification 45 97.24 Apoptosis 8 83.84 Adhesions 3 69.68 Cataract 19 5.00 Hyperplasia 2 5.00 Diabetes Mellitus 2 5.00 Cancer 2 5.00 Disease 2 5.00 Corneal Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, we have shown that AR-12 can induce LEC death when used at various concentrations in vitro and can decrease PCO formation in the canine lens capsule explant model.

AR-12 Positive_regulation (induce) of LEC in lens capsule associated with capsule opacification and death

1) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.86 Pain Relevance 0.16

General Comments

This test has worked.