INT347315

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 3 100.00 Very High Very High Very High
Stress 2 100.00 Very High Very High Very High
Cancer 22 99.88 Very High Very High Very High
Disease 15 97.92 Very High Very High Very High
Capsule Opacification 45 92.20 High High
Renal Cell Carcinoma 29 83.92 Quite High
Cataract 19 79.64 Quite High
Renal Cancer 2 58.68 Quite High
Tuberous Sclerosis 1 53.68 Quite High
Apoptosis 8 53.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The natural product rapamycin binds to an intracellular protein known as FK506-binding protein 12 (FKBP12) and the resultant protein-drug complex inhibits the kinase activity of mTOR.16 mTOR is a highly conserved intracellular multi functional signal transduction serine-threonine kinase, and is a key regulatory protein in cancer that recognizes stress signals (eg, nutrient and energy depletion, oxidative or hypoxic stress, and proliferative and survival signals) via the phosphotidylinositol 3 kinase-protein kinase (PI3K-AKT) pathway.
PI3K Binding (recognizes) of associated with stress, hypoxia and cancer
1) Confidence 0.19 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 1.03 Pain Relevance 0
ILK can influence a wide range of cellular processes in development and disease (proliferation, migration, EMT) [4], and many of these effects may be due to its activation of Akt and interaction with the PI3K pathway.
PI3K Binding (interaction) of associated with disease
2) Confidence 0.10 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.55 Pain Relevance 0

General Comments

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