INT34734

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.91
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DSG3) cell adhesion (DSG3) plasma membrane (DSG3)
Anatomy Link Frequency
T cell 2
Spinal 1
striatum 1
parabrachial nucleus 1
DSG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 99.48 Very High Very High Very High
parabrachial 2 99.04 Very High Very High Very High
Central grey 2 98.38 Very High Very High Very High
nociceptor 2 97.66 Very High Very High Very High
dorsal root ganglion 3 94.44 High High
Thalamus 1 92.96 High High
c fibre 4 90.32 High High
Nucleus accumbens 2 86.64 High High
Spinal cord 2 80.96 Quite High
Dorsal horn 2 64.56 Quite High
Disease Link Frequency Relevance Heat
Pemphigoid 111 98.68 Very High Very High Very High
Urological Neuroanatomy 11 98.62 Very High Very High Very High
Ganglion Cysts 3 93.96 High High
Disease 33 84.64 Quite High
Autoimmune Disease 12 83.16 Quite High
Cancer 3 42.52 Quite Low
Nociception 2 25.00 Low Low
Recurrence 18 13.96 Low Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rather, additional studies in PV patients and healthy subjects have further confirmed that T cell recognition of Dsg3 peptides is tightly restricted by distinct HLA class II alleles, but, also, have demonstrated that T cell recognition of distinct Dsg3 peptides is independent of the development of Pemphigus vulgaris [55].
Dsg3 Binding (recognition) of in T cell associated with pemphigoid
1) Confidence 0.48 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630706 Disease Relevance 0.73 Pain Relevance 0
Rather, additional studies in PV patients and healthy subjects have further confirmed that T cell recognition of Dsg3 peptides is tightly restricted by distinct HLA class II alleles, but, also, have demonstrated that T cell recognition of distinct Dsg3 peptides is independent of the development of Pemphigus vulgaris [55].
Dsg3 Binding (recognition) of in T cell associated with pemphigoid
2) Confidence 0.48 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630706 Disease Relevance 0.68 Pain Relevance 0
However, to our knowledge, none of the HLA-binding DSG3 peptides studied so far has produced possible therapeutical applications.
DSG3 Binding (binding) of
3) Confidence 0.31 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630706 Disease Relevance 0.62 Pain Relevance 0
The relation of thalamic terminal fibers in the ventral striatum with patch and matrix compartments, as defined by enkephalin-immunohistochemistry, was studied in adjacent or double-stained sections of the rat brain by combining anterograde tracing of Phaseolus vulgaris-leucoagglutinin (PHA-L) and enkephalin staining.
vulgaris-leucoagglutinin Binding (tracing) of in striatum associated with enkephalin
4) Confidence 0.00 Published 1988 Journal J. Chem. Neuroanat. Section Abstract Doc Link 3077313 Disease Relevance 0 Pain Relevance 0.40
Spinal termination patterns of canine identified A-delta and C spermatic polymodal receptors traced by intracellular labeling with Phaseolus vulgaris-leucoagglutinin.
vulgaris-leucoagglutinin Binding (labeling) of in Spinal associated with nociceptor
5) Confidence 0.00 Published 1993 Journal J. Comp. Neurol. Section Title Doc Link 8227530 Disease Relevance 0.27 Pain Relevance 0.60
The efferent projections from the periaqueductal gray matter (PAG) to the parabrachial nucleus (PB) were studied in the rat following microinjections of the anterograde axonal tracer Phaseolus vulgaris-leucoagglutinin (PHA-L) into restricted regions of the PAG.
vulgaris-leucoagglutinin Binding (microinjections) of in parabrachial nucleus associated with urological neuroanatomy, central grey and parabrachial
6) Confidence 0.00 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9826272 Disease Relevance 0.61 Pain Relevance 0.17

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