INT347380

Context Info Confidence 0.18 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.46 Pain Relevance 0.45

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg)

Anatomy Link Frequency liver 2 Ugcg (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 83 98.84 Analgesic 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Injury 11 99.16 Stress 9 89.00 Hepatotoxicity 9 70.48 Targeted Disruption 1 63.04 Overdose 6 5.00 Toxicity 2 5.00 Necrosis 2 5.00 Decapitation 2 5.00 Diabetes Mellitus 1 5.00 Apoptosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Protection by NAC, HYTAU and TAU against APAP-induced liver injury is also a reflection of their ability to prevent the loss of GCS activity to a toxic dose of APAP, an enzyme that plays a crucial role in protecting the liver against hepatotoxic compounds by regulating the de novo synthesis of GSH.

Negative_regulation (prevent) of Negative_regulation (loss) of GCS in liver associated with paracetamol and injury

1) Confidence 0.18 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.46 Pain Relevance 0.45

General Comments

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