INT347381

Context Info Confidence 0.19 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.82 Pain Relevance 1.58

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg)

Anatomy Link Frequency plasma 3 liver 1 Ugcg (Rattus norvegicus)

Pain Link Frequency Relevance Heat Paracetamol 166 98.88 Potency 2 73.04 Analgesic 2 5.00

Disease Link Frequency Relevance Heat Hepatotoxicity 18 97.08 Injury 22 79.20 Decapitation 4 77.44 Overdose 12 49.32 Stress 18 5.00 Toxicity 4 5.00 Necrosis 4 5.00 Diabetes Mellitus 2 5.00 Targeted Disruption 2 5.00 Apoptosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.

Regulation (influence) of Transcription (activities) of GCS in plasma associated with paracetamol

1) Confidence 0.19 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.41 Pain Relevance 0.79

By itself, APAP increased MDA formation and had a significant lowering influence on the levels of GSH and GSSG, the GSH/GSSH ratio, and the activities of GR, GST and GCS both in the plasma and liver.

Regulation (influence) of in liver Transcription (activities) of GCS in plasma associated with paracetamol

2) Confidence 0.06 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2994383 Disease Relevance 0.41 Pain Relevance 0.79

General Comments

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