INT34741
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Clonidine induced a greater total serum growth-hormone production in PD than in SND (p = 0.01). | |||||||||||||||
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While these data do not exclude the possibility of a short loop feedback control of GH secretion, they strongly suggest that the direction of the GH response to a provocative stimulus is determined by the antecedent GH level and that an alpha-adrenoreceptor mechanism is involved in such a biphasic modulation of GH levels. | |||||||||||||||
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While these data do not exclude the possibility of a short loop feedback control of GH secretion, they strongly suggest that the direction of the GH response to a provocative stimulus is determined by the antecedent GH level and that an alpha-adrenoreceptor mechanism is involved in such a biphasic modulation of GH levels. | |||||||||||||||
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Plasma levels of ACTH, somatotropin, glucose and free glycerol were markedly elevated in all patients (n = 20) intra- and postoperatively, whereas cortisol and prolactin remained unchanged. | |||||||||||||||
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Immunohistochemical analysis indicated positive reactivity for adrenocorticotropic hormone (ACTH) and growth hormone (GH), and in situ hybridization indicated the expression of proopiomelanocortin (POMC) and GH mRNA. | |||||||||||||||
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Previous investigations of patients with chronic renal failure have also observed reduced concentration of GHBP,24,38 which may indicate decreased expression of the GH receptor in target tissues, and hence diminished responsiveness to GH in renal failure. | |||||||||||||||
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However, this seems not to be the case as GH appeared to be well tolerated generally and no differences in the safety profiles between the two groups were observed. | |||||||||||||||
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As a first step to standardizing GH measurement", they "recommend the reporting of GH concentrations in ? | |||||||||||||||
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If the GH is above 0.4 ? | |||||||||||||||
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However, high GH concentrations can also be found in healthy subjects, owing to the episodic nature of GH secretion, that can fluctuate between undetectable levels (most of the time) and peaks of up to 30 ? | |||||||||||||||
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If GH and IGF-1 levels were still elevated in patients receiving lanreotide 120 mg every three weeks, the dose was increased to 180 mg, or 90 mg in each gluteal muscle, every three weeks. | |||||||||||||||
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At a preprogrammed time in a child's life there is an increase in the amplitude of GnRH pulses which triggers a cascade of events including increases in the amplitude of FSH and LH pulses, followed by marked increases in gonadal sex steroidal output, which in turn increases growth hormone (GH) and insulin-like growth factor-1 (IGF-1) production. | |||||||||||||||
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Both androgenic and estrogenic hormones markedly increase GH production rates as measured by deconvolution models in the prepubertal human, and compelling data strongly suggest that it is indeed the estrogen which controls the feedback amplification of GH production during puberty even in the male. | |||||||||||||||
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The disease is related to the excessive production of growth hormone (GH). | |||||||||||||||
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Acromegaly
Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. | |||||||||||||||
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1.2 SD over the course of 7 years.26 Factors that tend to predict a positive response to GH treatment include GH dose, degree of height deficit compared to parentsÂ’ heights, young age, and first year height velocity.1,34
Safety of GH treatment in ISS | |||||||||||||||
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Many who treat children with ISS believe that by increasing adult height they are improving quality of life.50 However, there is little objective data to support this notion.51 In fact, the idea that short stature is a problem that can be addressed by GH treatment has been recently challenged in the popular press.52 Recent reviews of available instruments for evaluating quality of life in children with GHD or ISS suggest that it should be possible to do the studies that could help answer whether treatment with GH has a positive or negative effect on quality of life.53,54 The question of efficacy of GH treatment is particularly relevant because of the expense of GH therapy: perhaps as much as US$52,634 per inch.55 In spite of the difficulty of demonstrating that an increase in height also results in increased quality of life, children with ISS have been treated with GH since at least the inception of the NCGS in 1985, accounting for approximately 20% of those patients treated with GH.56 Savage57 has suggested that 1) if growth hormone therapy is restricted to a height threshold of ? | |||||||||||||||
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Kamp et al demonstrated that the addition of GnRHa to GH therapy in children with ISS or intrauterine growth restriction resulted in an increase in predicted adult height of 8.0 cm in girls and 10.4 cm in boys.88 A prospective study comparing treatment of normal short girls with GH alone or with GH plus GnRHa suggested that while GH alone resulted in an increase in predicted adult height, the addition of GnRHa combined with GH resulted in an even greater increase in predicted adult height.89 The evaluation of two large GH registry databases,90 GH prediction models,90 and a recent report of lack of efficancy in increasing adult height when treatment is initiated after the age of 7–8 years91 do not support the success of this treatment. | |||||||||||||||
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An evaluation of data from children with ISS treated with GH, taken from a large GH database, showed that GH treatment resulted in an increase in height from ? | |||||||||||||||
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If the lowest GH value (nadir) during OGGT is below 1 ? | |||||||||||||||
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General Comments
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