INT347517

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Tbxa2r (Mus musculus)
ST7L (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 12 96.08 Very High Very High Very High
Kinase C 3 90.80 High High
Serotonin 21 77.80 Quite High
agonist 39 57.32 Quite High
Inflammation 45 13.84 Low Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 12 50.00 Quite Low
INFLAMMATION 57 13.84 Low Low
Bites And Stings 15 5.00 Very Low Very Low Very Low
Edema 12 5.00 Very Low Very Low Very Low
Coagulation Disorder 12 5.00 Very Low Very Low Very Low
Pruritus 9 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Erythema 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Salivary Gland Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both of these pathways are independent of TXA2, suggesting that the inhibition of collagen-mediated aggregation by AnSt-D7L1 depends only on its ability to bind TXA2.


TXA2 Binding (bind) of AnSt-D7L1
1) Confidence 0.00 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.17
This result is important in showing that AnSt-D7L1 is able to bind TXA2 itself, since in ITC experiments we were limited to the testing of stable analogues of TXA2.


TXA2 Binding (bind) of AnSt-D7L1
2) Confidence 0.00 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.12
To determine if AnSt-D7L1 is specific in its binding for CysLTs and TXA2, we screened a number of additional eicosanoid compounds using ITC.
TXA2 Binding (binding) of AnSt-D7L1
3) Confidence 0.00 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.04

General Comments

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