INT34755

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Context Info
Confidence 0.56
First Reported 1986
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.20
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2b1)
Anatomy Link Frequency
hepatocytes 1
Kupffer cells 1
Cyp2b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 6 92.36 High High
anesthesia 1 69.72 Quite High
Morphine 1 56.12 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 87.44 High High
Necrosis 3 86.44 High High
Cancer 3 86.08 High High
Toxicity 2 77.44 Quite High
Injury 4 75.00 Quite High
Suicidal Behaviour 2 75.00 Quite High
Poisoning 1 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This specific down-regulation of CYP2B1 was mediated exclusively by TNFalpha, released from the Kupffer cells.
Negative_regulation (regulation) of CYP2B1 in Kupffer cells
1) Confidence 0.56 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10096772 Disease Relevance 0.21 Pain Relevance 0.08
It is found that guaiazulene inhibited considerably CYP1A2 and CYP2B1 and had a weak effect on CYP1A1 in rat hepatic microsomal fractions.
Negative_regulation (inhibited) of CYP2B1
2) Confidence 0.53 Published 1997 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 9112807 Disease Relevance 0.24 Pain Relevance 0.33
The simultaneous treatment of the cocultures with phenobarbital and LPS (10 ng/ml) or 3-methylcholanthrene and LPS (10 ng/ml) resulted in a strong down-regulation (85%) of the phenobarbital-induced cytochrome P450 (CYP) isoform CYP2B1 in the hepatocytes whereas the 3-methylcholanthrene-induced isoform CYP1A1 was only weakly affected (15%).
Negative_regulation (down-regulation) of CYP2B1 in hepatocytes
3) Confidence 0.41 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10096772 Disease Relevance 0.24 Pain Relevance 0.07
The protein levels of CYP2B1 and 2E1 were significantly decreased by FFx; a decrease that was not prevented by GdCl3 treatment.
Negative_regulation (decreased) of CYP2B1
4) Confidence 0.37 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.44 Pain Relevance 0.07
However, the protein moiety of cytochrome P-450UT-H was not diminished and the immunoreactive protein for cytochromes P-450UT-F, P-450PB-B, and P-450ISF-G was only slightly decreased.
Negative_regulation (decreased) of P-450PB-B
5) Confidence 0.06 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3080674 Disease Relevance 0.07 Pain Relevance 0.06

General Comments

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