INT3476

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 0
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
plasma 1
retina 1
band 1
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 28 99.58 Very High Very High Very High
opiate 2 99.44 Very High Very High Very High
Morphine 12 99.40 Very High Very High Very High
addiction 2 99.22 Very High Very High Very High
tolerance 2 98.86 Very High Very High Very High
withdrawal 2 98.40 Very High Very High Very High
Enkephalin 8 97.94 Very High Very High Very High
narcan 6 97.44 Very High Very High Very High
Immobilon 4 97.08 Very High Very High Very High
methadone 4 96.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 15 17.76 Low Low
Ganglion Cysts 9 5.00 Very Low Very Low Very Low
Diphtheria 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine, in vitro, did not alter the phosphorylation of any SPM proteins in the assay, although at a high concentration morphine did antagonize the calcium-stimulated phosphorylation of one or more proteins in band II.
Phosphorylation (phosphorylation) of SPM in band associated with morphine
1) Confidence 0.48 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 759619 Disease Relevance 0 Pain Relevance 0.70
The development of tolerance to and dependence on opiates may include changes in the phosphorylation of specific SPM proteins.
Phosphorylation (phosphorylation) of SPM associated with addiction, tolerance and opiate
2) Confidence 0.36 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 759619 Disease Relevance 0 Pain Relevance 0.68
Immunoprecipitation of GluR1 was performed after the back phosphorylation of retinal SPM proteins (described above) using an immunoprecipitation kit (Protein G; Boehringer Mannheim, Indianapolis, IN).
Phosphorylation (phosphorylation) of SPM
3) Confidence 0.32 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
To determine if GluR1 phosphorylation by CaMKII in vivo is altered in the rdta retina, the SPM proteins of the rdta retina and their littermate controls are back phosphorylated by endogenous CaMKII in the presence of Ca2+/CaM (1 mM CaCl2 and 0.02 mg/ml calmodulin).
Phosphorylation (phosphorylated) of SPM in retina
4) Confidence 0.32 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
To test this notion, the SPM proteins isolated from the retinae of the rdta and their littermate controls mice were back-phosphorylated in the presence of Ca2+/calmodulin and ?
Phosphorylation (phosphorylated) of SPM
5) Confidence 0.24 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.03
The acute administration of morphine, methadone, etorphine, methionine-enkephalin, leucine-enkephalin and some related pharmacologically active peptides to rats produces biphasic effects on the degree of phosphorylation of striatal synaptic plasma membrane (SPM) proteins by endogenous protein kinases in the membranes.
Phosphorylation (phosphorylation) of SPM in plasma associated with enkephalin, methadone, immobilon and morphine
6) Confidence 0.19 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 0.80
Neither modulators, added separately or together to the assay, was able to restore a depressed phosphorylation to normal levels, although each modulator was effective in stimulating the phosphorylation of many SPM proteins.
Phosphorylation (phosphorylation) of SPM
7) Confidence 0.15 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 0.67
At 1 to 5 min after opioid administration, the phosphorylation of several SPM proteins is enhanced, followed at 10 to 20 min by a severe reduction in the rate of phosphorylation of the same proteins.
Phosphorylation (phosphorylation) of SPM associated with opioid
8) Confidence 0.15 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 0.90
The injection of saline or an inactive narcotic isomer has no effect on the phosphorylation of striatal SPM proteins.
Phosphorylation (phosphorylation) of SPM
9) Confidence 0.15 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 1.06

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