INT347628

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hist1h3f) molecular_function (Hist1h3f) biological_process (Hist1h3f)
Hist1h3f (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 4 31.28 Quite Low
tolerance 1 20.52 Low Low
fibrosis 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Antiemetics 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 1 99.80 Very High Very High Very High
Follicular Lymphoma 1 97.24 Very High Very High Very High
Lymphatic System Cancer 22 86.68 High High
Cancer 77 75.60 Quite High
Apoptosis 31 74.24 Quite High
Myeloid Leukemia 5 70.92 Quite High
Acute Myeloid Leukemia 1 70.72 Quite High
Hematologic Neoplasms 14 68.16 Quite High
Solid Tumor 21 59.68 Quite High
Multiple Myeloma 9 58.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 5, VPA markedly increased acetyl-histone H3 expression with maximal induction at 12 h of incubation with VPA.
Positive_regulation (increased) of Gene_expression (expression) of acetyl-histone H3
1) Confidence 0.19 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.28 Pain Relevance 0
An increase in the acetylation levels of histone H3 with a maximum effect 8 h after dosing could be seen, but also only in the 200-mg cohort.
Positive_regulation (increase) of Gene_expression (levels) of histone H3
2) Confidence 0.05 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.99 Pain Relevance 0

General Comments

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