INT34767

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 36
Total Number 36
Disease Relevance 14.79
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGIR) cell-cell signaling (PTGIR) signal transducer activity (PTGIR)
Anatomy Link Frequency
platelet 4
endothelial cells 3
alveolar macrophages 2
blood 2
Th2 cells 2
PTGIR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 194 98.88 Very High Very High Very High
tetrodotoxin-resistant sodium channels 10 98.56 Very High Very High Very High
agonist 201 98.04 Very High Very High Very High
cINOD 406 97.92 Very High Very High Very High
ischemia 22 97.44 Very High Very High Very High
rheumatoid arthritis 73 96.94 Very High Very High Very High
aspirin 161 96.76 Very High Very High Very High
Pain 166 95.68 Very High Very High Very High
bradykinin 66 94.68 High High
Inflammatory mediators 23 94.24 High High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 379 99.72 Very High Very High Very High
Targeted Disruption 27 99.70 Very High Very High Very High
Injury 24 99.30 Very High Very High Very High
Increased Venous Pressure Under Development 153 99.08 Very High Very High Very High
INFLAMMATION 281 98.88 Very High Very High Very High
Hypersensitivity 32 98.54 Very High Very High Very High
Disease 214 97.92 Very High Very High Very High
Hyperalgesia 40 97.64 Very High Very High Very High
Pre-eclampsia 171 97.44 Very High Very High Very High
Coronary Artery Disease 29 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is assumed that PGE2/PGI2 production and the renin angiotensin production influence each other physiologically.
Gene_expression (production) of PGI2 in PGE2
1) Confidence 0.42 Published 1986 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 3082707 Disease Relevance 0.41 Pain Relevance 0
In contrast to fetal osteocytes, adult osteocytes do not express the IP receptor.
Neg (not) Gene_expression (express) of IP receptor in osteocytes
2) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592809 Disease Relevance 0.54 Pain Relevance 0.26
We will describe possible strategies to reduce the side effects of etoricoxib by using biochemical markers of COX inhibition, such as whole blood COX-2 and the assessment of prostacyclin biosynthesis in vivo.



Gene_expression (biosynthesis) of prostacyclin in blood
3) Confidence 0.19 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2621416 Disease Relevance 0.15 Pain Relevance 0.15
Although endothelial cells may generate a different array of the prostanoids PGD2, PGE2, and prostacyclin along the vascular beds, there is robust evidence that prostacyclin is the dominant prostanoid produced in the macrocirculation (Moncada et al 1977; Grosser et al 2006).
Gene_expression (produced) of prostacyclin in endothelial cells
4) Confidence 0.19 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.31 Pain Relevance 0.07
Similarly to inhibition of prostacyclin biosynthesis or activity, the novel imidazole-based HO-1 inhibitor QC15 reversed TNF-alpha reduction by LSS.
Gene_expression (biosynthesis) of prostacyclin associated with stress
5) Confidence 0.19 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 0.84 Pain Relevance 0.37
Studies in knockout (KO) mice for prostacyclin receptor (IP) and the recent findings of acceleration of CV disease in humans by a dysfunctional IP mutation convincingly support the protective role of prostacyclin for the CV system (Arehart et al 2008; Patrignani et al 2008b).


Gene_expression (receptor) of prostacyclin associated with targeted disruption and disease
6) Confidence 0.19 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.20 Pain Relevance 0.12
This may occur in the kidney where COX-2 is the source of vasodilatory prostacyclin and COX-1 is the source of vasoconstrictor TXA2 (Qi et al 2002; Grosser et al 2006).
Gene_expression (source) of prostacyclin in kidney
7) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.35 Pain Relevance 0.35
Others reported that alveolar macrophages are able to synthesize large amount of PGI2 [4].
Gene_expression (synthesize) of PGI2 in alveolar macrophages
8) Confidence 0.17 Published 2007 Journal Cough Section Body Doc Link PMC1781075 Disease Relevance 1.21 Pain Relevance 0.23
Others reported that alveolar macrophages are able to synthesize a large amount of PGI2 [4].
Gene_expression (synthesize) of PGI2 in alveolar macrophages
9) Confidence 0.17 Published 2007 Journal Cough Section Body Doc Link PMC1781075 Disease Relevance 0.91 Pain Relevance 0.09
For all these biological actions, prostacyclin has on the distinctive features of a cardioprotective mediator.
Gene_expression (has) of prostacyclin
10) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.23 Pain Relevance 0.11
[a biomarker of prostacyclin biosynthesis in vivo (Figure 4)] – in association with genetic biomarkers (such as polymorphisms in the prostacyclin receptor IP) (Arehart et al 2008) may be surrogate end-points of CV hazard by pharmacological inhibition of COX-2 (Patrignani et al 2008b).


Gene_expression (biosynthesis) of prostacyclin
11) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.44 Pain Relevance 0.43
However, further studies of clinical pharmacology in patients with OA and RA should be performed to verify the impact of etoricoxib 30 mg on biochemical markers of COX inhibition, such as whole blood COX-2 and systemic and renal biosynthesis of prostacyclin and TXA2.



Gene_expression (biosynthesis) of prostacyclin in blood associated with rheumatoid arthritis
12) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.30 Pain Relevance 0.39
In addition, coxibs and tNSAIDs inhibit profoundly prostacyclin generation in vivo, as assessed by the measurement of urinary levels of a major enzymatic metabolite 2,3-dinor-6-keto-PGF1?
Gene_expression (generation) of prostacyclin
13) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.25 Pain Relevance 0.23
PGE2 and prostacyclin, produced in the peripheral terminals of sensory nerve endings, are hyperalgesic and enhance nociception produced by other mediators (such as bradykinin) (Murata et al 1997; Nakao et al 2007).
Gene_expression (produced) of prostacyclin in sensory nerve associated with nociception, hyperalgesia and bradykinin
14) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 1.48 Pain Relevance 1.12
However, their use has unravelled the important protective role of COX-2 for the cardiovascular (CV) system, mainly through the generation of prostacyclin.
Gene_expression (generation) of prostacyclin
15) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2621416 Disease Relevance 0.17 Pain Relevance 0.35
PGD2 mediates allergic and inflammatory reactions through two distinct types of receptors: the D-type prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2).
Gene_expression (expressed) of D-type prostanoid receptor in Th2 cells associated with inflammation and hypersensitivity
16) Confidence 0.10 Published 2011 Journal Journal of Synchrotron Radiation Section Body Doc Link PMC3004263 Disease Relevance 0.61 Pain Relevance 0.26
PGI2 is the major vasodilator within the prostaglandin cascade and is synthesized predominantly by the endothelium[11].
Gene_expression (synthesized) of PGI2 in endothelium
17) Confidence 0.10 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0 Pain Relevance 0
When the relative IC50 of COX inhibitors increased above 10, we observed a strong inhibition on the production of PGI2, whereas the production of TXA2 was hardly affected.
Gene_expression (production) of PGI2
18) Confidence 0.09 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.50 Pain Relevance 0.42
Human endothelial cells exposed to H2O2 demonstrate decreased prostacyclin (PGI2) synthesis due to decreased prostaglandin H synthase (PGH synthase) activity.
Gene_expression (synthesis) of prostacyclin in endothelial cells
19) Confidence 0.09 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8997188 Disease Relevance 0.09 Pain Relevance 0.09
Following the discovery that prostacyclin and thromboxane levels are disturbed in the maternal circulation in preeclampsia, a number of centers have performed clinical trials with low dose aspirin, believing that treatment with cyclooxygenase inhibitors could prevent or ameliorate the disorder by reducing platelet TXA2 production while sparing endothelial PGI2 synthesis.
Gene_expression (synthesis) of PGI2 in platelet associated with aspirin and pre-eclampsia
20) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.54 Pain Relevance 0.05

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