INT34768

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Context Info
Confidence 0.25
First Reported 1984
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.79
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
blood 4
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 6 96.52 Very High Very High Very High
bradykinin 18 95.12 Very High Very High Very High
beta blocker 7 94.80 High High
Enkephalin 4 93.44 High High
imagery 4 89.20 High High
Angina 7 86.64 High High
antagonist 11 82.88 Quite High
Clonidine 3 57.36 Quite High
ischemia 9 55.36 Quite High
Inflammation 9 50.48 Quite High
Disease Link Frequency Relevance Heat
Syndrome 48 98.72 Very High Very High Very High
Hypertension 72 98.08 Very High Very High Very High
Renal Failure 1 97.92 Very High Very High Very High
Myocardial Infarction 33 96.28 Very High Very High Very High
Pressure And Volume Under Development 13 90.92 High High
Liver Disease 1 89.60 High High
Natriuresis 10 86.64 High High
Cv General 3 Under Development 4 86.64 High High
Stress 4 85.20 High High
Congenital Anomalies 1 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACE inhibitors such as captopril and enalapril act by inhibiting the conversion of angiotensin I to angiotensin II thereby decreasing the vasoconstrictor effect of angiotensin II and the aldosterone production secondary to angiotensin II stimulation.
Negative_regulation (inhibiting) of Negative_regulation (conversion) of angiotensin I
1) Confidence 0.25 Published 1984 Journal J Hypertens Suppl Section Abstract Doc Link 6152830 Disease Relevance 0 Pain Relevance 0.14
ACE inhibitors such as captopril and enalapril act by inhibiting the conversion of angiotensin I to angiotensin II thereby decreasing the vasoconstrictor effect of angiotensin II and the aldosterone production secondary to angiotensin II stimulation.
Negative_regulation (decreasing) of Negative_regulation (effect) of angiotensin II
2) Confidence 0.25 Published 1984 Journal J Hypertens Suppl Section Abstract Doc Link 6152830 Disease Relevance 0 Pain Relevance 0.14
ACE inhibitors such as captopril and enalapril act by inhibiting the conversion of angiotensin I to angiotensin II thereby decreasing the vasoconstrictor effect of angiotensin II and the aldosterone production secondary to angiotensin II stimulation.
Negative_regulation (inhibiting) of Negative_regulation (conversion) of angiotensin II
3) Confidence 0.25 Published 1984 Journal J Hypertens Suppl Section Abstract Doc Link 6152830 Disease Relevance 0 Pain Relevance 0.14
Both drugs caused a decrease in angiotensin (Ang) II level, an increase in Ang I level, and reduction in Ang II/Ang I ratio in arterial and coronary sinus blood.
Negative_regulation (decrease) of Negative_regulation (reduction) of angiotensin in blood
4) Confidence 0.13 Published 2003 Journal Hypertension Section Abstract Doc Link 12623947 Disease Relevance 0.09 Pain Relevance 0.34
In support of this concept it has been shown that the pregnancy-specific reduction in vasoconstrictor action of angiotensin, is abolished when prostaglandin synthesis inhibitors are given.
Negative_regulation (abolished) of Negative_regulation (reduction) of angiotensin
5) Confidence 0.11 Published 1986 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 3082707 Disease Relevance 0.35 Pain Relevance 0
ACE inhibitor plus angiotensin receptor blocker
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of angiotensin
6) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.50 Pain Relevance 0.03
As RAAS has been implicated in oxidative damage, its interruption though ACE inhibition or angiotensin blockade may prevent the development of CRS.
Negative_regulation (inhibition) of Negative_regulation (blockade) of angiotensin associated with syndrome
7) Confidence 0.04 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 0.89 Pain Relevance 0.15
The main exclusion criteria were clinical signs of heart failure requiring treatment; systolic blood pressure <100 mmHg; uncontrolled treated hypertension with systolic blood pressure >180 mmHg and/or a diastolic blood pressure >100 mmHg; use of ACE inhibitors or angiotensin II receptor inhibitors within 1 month prior to the first selection visit; renal failure with serum creatinine >150 ?
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of angiotensin II in blood associated with renal failure, hypertension and myocardial infarction
8) Confidence 0.04 Published 2007 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2039813 Disease Relevance 0.98 Pain Relevance 0.12
The affinities of the IRAP inhibitors angiotensin IV, Nle1-angiotensin IV, and LVV-hemorphin-7 were selectively decreased.
Negative_regulation (decreased) of Negative_regulation (inhibitors) of Nle1-angiotensin IV
9) Confidence 0.01 Published 2007 Journal Biol. Chem. Section Abstract Doc Link 17391061 Disease Relevance 0 Pain Relevance 0.18
The affinities of the IRAP inhibitors angiotensin IV, Nle1-angiotensin IV, and LVV-hemorphin-7 were selectively decreased.
Negative_regulation (decreased) of Negative_regulation (inhibitors) of angiotensin IV
10) Confidence 0.01 Published 2007 Journal Biol. Chem. Section Abstract Doc Link 17391061 Disease Relevance 0 Pain Relevance 0.18

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