INT3477

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.87
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
bands 1
MMA 1
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 2 99.56 Very High Very High Very High
Morphine 5 91.84 High High
cytokine 3 83.28 Quite High
Inflammation 9 82.52 Quite High
fibrosis 2 68.80 Quite High
narcan 1 53.12 Quite High
withdrawal 1 51.36 Quite High
intrathecal 1 48.48 Quite Low
Inflammatory response 1 37.68 Quite Low
tolerance 1 31.28 Quite Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 8 99.84 Very High Very High Very High
Disease 230 98.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 97.68 Very High Very High Very High
Death 13 97.24 Very High Very High Very High
Nicotine Addiction 30 84.88 Quite High
INFLAMMATION 12 82.52 Quite High
Cardiovascular Disease 2 80.88 Quite High
Atherosclerosis 12 75.20 Quite High
Pulmonary Disease 4 73.84 Quite High
Cystic Fibrosis 2 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most recent studies [65] indicate that the role of NPC2/NPC1 proteins in cholesterol transport is restricted to lysosomal export.
Regulation (role) of NPC1
1) Confidence 0.45 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0 Pain Relevance 0
Myelin lipids are markedly affected in the NPC1 mouse model but in patients, a significant decrease is only seen in the early infantile neurological onset form [18,60].


Regulation (affected) of NPC1
2) Confidence 0.39 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.17 Pain Relevance 0
The underlying gene, NPC1 responsible for 95% of Niemann-Pick type C disease, encodes a multispanning membrane protein containing a sterol-sensing domain that is required for the egress of cholesterol from late endosomes [9].
Regulation (responsible) of NPC1 associated with disease
3) Confidence 0.27 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.76 Pain Relevance 0
Phosphate was incorporated into several SPM protein bands, two of which were regulated by cyclic adenosine 3':5' monophosphate.
Regulation (regulated) of SPM in bands associated with adenocard
4) Confidence 0.16 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 759619 Disease Relevance 0 Pain Relevance 0.36
However, D-SPM/pDNA administration with plasmid controlled by CMV promoter only resulted in a transient reporter gene expression.
Regulation (controlled) of D-SPM/pDNA associated with cytomegalovirus infection
5) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.61 Pain Relevance 0.12
Intranasal delivery of the naked pDNA and D-SPM controls exhibited background reading of the naïve mice (44.34 ± 4.51?
Regulation (controls) of D-SPM
6) Confidence 0.16 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
Their work suggests that the PBCA, MMA-SPM, and SLNs seem promising for the drug delivery and clinical applications in neuro-AIDS treatment.


Spec (seem) Regulation (promising) of MMA-SPM in MMA associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.00 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2847536 Disease Relevance 0.32 Pain Relevance 0

General Comments

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