INT34772

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Context Info
Confidence 0.32
First Reported 1986
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1, IGF1) extracellular region (GH1, IGF1) signal transduction (IGF1)
Anatomy Link Frequency
plasma 1
GH1 (Homo sapiens)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 98.52 Very High Very High Very High
Clonidine 4 85.20 High High
methotrexate 2 73.76 Quite High
cytokine 16 59.04 Quite High
Inflammatory marker 1 49.72 Quite Low
Inflammatory response 1 46.00 Quite Low
Inflammation 9 44.00 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 77 98.52 Very High Very High Very High
Hypoglycemia 1 81.08 Quite High
Obesity 14 60.56 Quite High
Growth Problems 1 50.08 Quite High
INFLAMMATION 11 49.40 Quite Low
Critical Illness 1 34.24 Quite Low
Liver Disease 2 33.16 Quite Low
Disease 9 9.76 Low Low
Appetite Loss 8 5.00 Very Low Very Low Very Low
Renal Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While participation of the IGFs/somatomedins in this feedback loop cannot be excluded, the inhibitory effects of exogenous GH do not depend directly on circulating plasma IGF-I or IGF-II levels.
GH Neg (not) Regulation (depend) of IGF-I in plasma
1) Confidence 0.32 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3082919 Disease Relevance 0.05 Pain Relevance 0.22
Although we are unaware of reports in which IGF-I and IGFBP responses to exogenous GH have been compared in patients with RA and healthy control subjects, the present study and other studies suggest that RA is associated with GH resistance or insensitivity.
GH Regulation (responses) of IGF-I associated with rheumatoid arthritis
2) Confidence 0.02 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.90 Pain Relevance 0.47

General Comments

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