INT34777
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Another approach was described by De Ceuninck et al [55], who noted that disruption of IGF-1 binding to the inhibitory binding proteins via small molecules, resulting in the release of free IGF-1, restores the anabolic response of human chondrocytes. | |||||||||||||||
| |||||||||||||||
|
IGF-I receptor localized on sSMCs and their processes and colocalized with IGF-I. | |||||||||||||||
| |||||||||||||||
|
In addition, growth hormone (GH) secretion and serum insulin-like growth factor (IGF)-I levels fall. | |||||||||||||||
| |||||||||||||||
|
This suggested resistance of the liver and other somatomedin-C secreting tissues to GH. | |||||||||||||||
| |||||||||||||||
|
In severely short patients with normal GH response to provocative test, and additionally extremely low IGF-1 and/or IGFBP-3, an IGF-1 generation test can be helpful to confirm the diagnosis of IGFD. | |||||||||||||||
| |||||||||||||||
|
In severely short patients with normal GH response to provocative test, and additionally extremely low IGF-1 and/or IGFBP-3, an IGF-1 generation test can be helpful to confirm the diagnosis of IGFD. | |||||||||||||||
| |||||||||||||||
|
Otherwise, primary GHI or IGFD is due to congenital resistance to GH action with low or absent peripheral IGF-1.2 This syndrome, also known as Laron syndrome, was first described by Laron in the late 1960s as pituitary dwarfisms with high serum GH.2 It is a very rare syndrome resulting from genetic abnormality of GH receptor, mainly occurring in patients with high consanguinity.2,5 | |||||||||||||||
| |||||||||||||||
|
These results suggest that amphid neurons are important for insulin/IGF-1 signaling and that ethosuximide may extend lifespan by disrupting this pathway. | |||||||||||||||
| |||||||||||||||
|
Determination of IGFPB3, IGF-1, and GH Levels | |||||||||||||||
| |||||||||||||||
|
Human growth hormone and somatomedin C suppress the spontaneous release of growth hormone in unanesthetized rats. | |||||||||||||||
| |||||||||||||||
|
[From research of non-suppressible serum insulin activity to the clinical application of recombinant insulin-like growth factor (rhIGF-I)]. | |||||||||||||||
| |||||||||||||||
|
She was given a treatment with lanreotide 60 mg every four weeks and her IGF-1 levels decreased (Table 1). | |||||||||||||||
| |||||||||||||||
|
The study showed an autocrine/paracrine mechanism of IGF-1 secretion, and the stimulative effect of IGF-1 on proteoglycan synthesis in bovine IVD. | |||||||||||||||
| |||||||||||||||
|
The results presented in this report showed the response to IGF-1 was less striking in 1%FBS, but a marked elevation in cell proliferation and the dose-dependent effect was found between the concentrations of 10100 ? | |||||||||||||||
| |||||||||||||||
|
IGF-I localized primarily in synthetic smooth muscle cells (sSMCs) in both de novo and restenotic plaques. | |||||||||||||||
| |||||||||||||||
|
In all the children IGF-I and IGFBP-3 secretion was measured in a single blood sample during in morning hours. | |||||||||||||||
| |||||||||||||||
|
As a matter of fact, a direct effect of thyroid function on IGF-I secretion was not fully confirmed in our study, as there were no significant differences in an increase of IGF-I secretion between the euthyroid children and those, who presented with hypothyroidism during rhGH administration. | |||||||||||||||
| |||||||||||||||
|
Statistical analysis included comparison of thyroid function (FT4 and TSH concentrations), IGF-I secretion (as IGF-I SDS) and its bioavailability (expressed as IGF-I/IGFBP-3 molar ratio) in particular time points, before and during rhGH therapy. | |||||||||||||||
| |||||||||||||||
|
According to our observations, the therapy with rhGH led to a similar increase of IGF-I secretion and of its bioavailability in the patients with different forms of disorders of GH secretion and activity. | |||||||||||||||
| |||||||||||||||
|
Similarly, Bona et al. [28] documented that in the patients with hypothyroidism - both congenital and caused by thyroiditis - L-T4 replacement led to physiological increase of IGF-I and IGFBP-3 secretion. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.