INT34778

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Context Info
Confidence 0.62
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.78
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF2) extracellular region (IGF2) carbohydrate metabolic process (IGF2)
Anatomy Link Frequency
embryo 1
plasma 1
hearts 1
IGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 98.40 Very High Very High Very High
Angina 2 94.48 High High
Clonidine 4 89.88 High High
Dopamine 83 89.28 High High
midbrain 20 55.88 Quite High
chemokine 2 50.00 Quite Low
Pain 1 42.08 Quite Low
Thoracotomy 2 29.80 Quite Low
positron emission tomography 1 19.84 Low Low
Substantia nigra 1 18.00 Low Low
Disease Link Frequency Relevance Heat
Pleural Solitary Fibrous Tumor 12 99.90 Very High Very High Very High
Hypoglycemia 2 99.00 Very High Very High Very High
Hypertrophic Cardiomyopathy 5 98.70 Very High Very High Very High
Coronary Heart Disease 3 98.56 Very High Very High Very High
Cancer 53 96.96 Very High Very High Very High
Cv Unclassified Under Development 1 96.00 Very High Very High Very High
Cv General 3 Under Development 1 94.48 High High
Syndrome 1 94.00 High High
Medulloblastoma 1 93.48 High High
Charcot Marie Tooth Disease 1 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While participation of the IGFs/somatomedins in this feedback loop cannot be excluded, the inhibitory effects of exogenous GH do not depend directly on circulating plasma IGF-I or IGF-II levels.
Localization (participation) of IGF-II in plasma
1) Confidence 0.62 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3082919 Disease Relevance 0.05 Pain Relevance 0.28
Decreases in IGF-2 mRNA levels and IGF-2 secretion using growth hormone-releasing hormone antagonists were associated with decreased cancer cell proliferation in vitro [32] and tumor growth in vivo [33,34].
Localization (secretion) of IGF-2 associated with cancer and antagonist
2) Confidence 0.55 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2837867 Disease Relevance 1.43 Pain Relevance 0.05
In less than 5% of cases, SFTP can secrete insulin-like growth factor II which causes refractory hypoglycemia [1,7].
Localization (secrete) of insulin-like growth factor II associated with hypoglycemia and pleural solitary fibrous tumor
3) Confidence 0.51 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2531110 Disease Relevance 2.36 Pain Relevance 0
Co-localization of IGF2 and IGFBP4 mRNAs as revealed by in situ hybridization studies suggests a correlation between these two proteins in the developing embryo [64].
Localization (localization) of IGF2 in embryo
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.17
To investigate involvement of growth factors on myocardial hypertrophy in HCM patients, we evaluated gene expression and cellular localization of transforming growth factor-beta1 (TGF-beta1), insulin-like growth factors (IGF-I and IGF-II), and platelet-derived growth factor-B (PDGF-B) in ventricular biopsies obtained from patients with HCM (n=8), aortic stenosis (AS) (n=8), or stable angina (SA) (n=8) and from explanted hearts with ischemic cardiomyopathy (TM) (n=7).
Localization (localization) of IGF-II in hearts associated with angina, hypertrophic cardiomyopathy, cv unclassified under development and coronary heart disease
5) Confidence 0.04 Published 1997 Journal Circulation Section Abstract Doc Link 9264495 Disease Relevance 0.93 Pain Relevance 0.09

General Comments

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