INT34779

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 4.34
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF2) extracellular region (IGF2) carbohydrate metabolic process (IGF2)
Anatomy Link Frequency
Plasma 4
uterus 1
IGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 4 100.00 Very High Very High Very High
anesthesia 1 99.88 Very High Very High Very High
halothane 1 97.56 Very High Very High Very High
Clonidine 8 90.44 High High
Dopamine 83 79.76 Quite High
midbrain 20 46.36 Quite Low
chemokine 2 40.48 Quite Low
Substantia nigra 1 36.88 Quite Low
alcohol 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 20 98.92 Very High Very High Very High
Apoptosis 81 98.40 Very High Very High Very High
Cancer 183 93.40 High High
Adenocarcinoma 100 88.16 High High
Disease 29 87.24 High High
Adenoma 47 86.88 High High
Uterine Fibroids 72 86.24 High High
Growth Problems 2 81.24 Quite High
Leukemia 5 75.84 Quite High
Stomach Cancer 1 14.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma insulin-like growth factor (IGF-II) concentrations did not change after GH administration.
Neg (not) Regulation (change) of IGF-II in Plasma
1) Confidence 0.38 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3082919 Disease Relevance 0.08 Pain Relevance 0.31
Plasma insulin-like growth factor (IGF-II) concentrations did not change after GH administration.
Neg (not) Regulation (change) of Plasma insulin-like growth factor in Plasma
2) Confidence 0.38 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3082919 Disease Relevance 0.08 Pain Relevance 0.32
Plasma and tissue IGFBPs modulate the bioavailability of IGF-I and IGF-II and possess anti-proliferative and pro-apoptotic properties.
Regulation (modulate) of IGF-II in Plasma associated with apoptosis and bioavailability
3) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.03 Pain Relevance 0.05
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3, also known as IMP3 or KOC) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 (IGF-2) and ACTB (beta-actin).


Regulation (regulates) of IGF-2
4) Confidence 0.19 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2837867 Disease Relevance 0.72 Pain Relevance 0
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3, also known as IMP3 or KOC) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 (IGF-2) and ACTB (beta-actin).


Regulation (regulates) of insulin-like growth factor-2
5) Confidence 0.19 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2837867 Disease Relevance 0.71 Pain Relevance 0
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3, also known as IMP3 or KOC) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 (IGF-2) and ACTB (beta-actin).


Regulation (targets) of IGF-2
6) Confidence 0.19 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2837867 Disease Relevance 0.71 Pain Relevance 0
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3, also known as IMP3 or KOC) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 (IGF-2) and ACTB (beta-actin).


Regulation (targets) of insulin-like growth factor-2
7) Confidence 0.19 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2837867 Disease Relevance 0.71 Pain Relevance 0
We believe that involvement of IGFBP4 in the SDIA effect may be linked to regulation of IGF2 activity, and in our study, IGFBP4 seemed to decrease the survival of differentiating NPC.
Regulation (regulation) of IGF2
8) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.08
Rapid changes in plasma concentrations of insulin-like growth factor-I (IGF-I), IGF-II and IGF-binding proteins during anaesthesia in young sheep.
Regulation (changes) of IGF-II in plasma associated with anesthesia
9) Confidence 0.10 Published 1994 Journal J. Endocrinol. Section Title Doc Link 7520930 Disease Relevance 0 Pain Relevance 0.15
Insulin-like growth factor II (IGF2) was regulated in the estrogen-treated rat uterus (Table 3), but had previously been reported to be estrogen non-responsive.
Regulation (regulated) of IGF2 in uterus
10) Confidence 0.07 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.30 Pain Relevance 0

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