INT3478

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Context Info
Confidence 0.53
First Reported 1979
Last Reported 1990
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 6
Disease Relevance 0.16
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) extracellular region (Atrn)
plasma membrane (Atrn) molecular_function (Atrn) cytoplasm (Atrn)
Anatomy Link Frequency
plasma 2
striatum 1
Atrn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 99.62 Very High Very High Very High
Opioid 18 99.54 Very High Very High Very High
Immobilon 6 98.88 Very High Very High Very High
methadone 4 98.04 Very High Very High Very High
Enkephalin 4 97.94 Very High Very High Very High
adenocard 2 80.84 Quite High
lidocaine 3 75.00 Quite High
narcan 3 74.92 Quite High
agonist 2 73.72 Quite High
Clonidine 2 66.12 Quite High
Disease Link Frequency Relevance Heat
Shock 1 92.96 High High
Rupture 1 68.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membrane potential recordings suggested that membrane integrity and phosphorylation capacity were negatively affected at high drug concentrations (greater than 10(-3) M), especially in the case of tetracaine and dibucaine, when 5 x 10(-3) M even produced the collapse of the membrane potential and complete loss of the phosphorylation ability.
Phosphorylation (phosphorylation) of membrane associated with shock
1) Confidence 0.53 Published 1990 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2397219 Disease Relevance 0.16 Pain Relevance 0.21
The effect of morphine on the endogenous phosphorylation of synaptic plasma membrane proteins of rat striatum.
Phosphorylation (phosphorylation) of membrane in plasma associated with morphine
2) Confidence 0.21 Published 1979 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 759619 Disease Relevance 0 Pain Relevance 0.42
The role of calmodulin in opioid-induced changes in the phosphorylation of rat striatal synaptic membrane proteins.
Phosphorylation (phosphorylation) of membrane associated with opioid and immobilon
3) Confidence 0.06 Published 1982 Journal Neurochem. Res. Section Title Doc Link 7177312 Disease Relevance 0 Pain Relevance 0.53
Chronic morphine treatment of rats decreased the level of phosphorylation of synaptic membrane proteins of the striatum assayed in vitro.
Phosphorylation (phosphorylation) of membrane in striatum associated with morphine
4) Confidence 0.06 Published 1982 Journal Neurochem. Res. Section Abstract Doc Link 7177312 Disease Relevance 0 Pain Relevance 0.42
The effect of acute opioid administration on the phosphorylation of rat striatal synaptic membrane proteins.
Phosphorylation (phosphorylation) of membrane associated with opioid
5) Confidence 0.03 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6276532 Disease Relevance 0 Pain Relevance 1.01
The acute administration of morphine, methadone, etorphine, methionine-enkephalin, leucine-enkephalin and some related pharmacologically active peptides to rats produces biphasic effects on the degree of phosphorylation of striatal synaptic plasma membrane (SPM) proteins by endogenous protein kinases in the membranes.
Phosphorylation (phosphorylation) of membrane in plasma associated with enkephalin, methadone, immobilon and morphine
6) Confidence 0.03 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 0.80

General Comments

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