INT34790

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Context Info
Confidence 0.43
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 11.34
Pain Relevance 3.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
hippocampus 3
cerebellum 3
neuronal 1
nodes 1
puncture 1
KCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
electroacupuncture 91 100.00 Very High Very High Very High
Acupuncture 75 100.00 Very High Very High Very High
Hippocampus 70 100.00 Very High Very High Very High
Inflammation 43 99.40 Very High Very High Very High
Hyperalgesia 14 98.72 Very High Very High Very High
potassium channel 830 98.42 Very High Very High Very High
narcan 4 91.20 High High
Pain 46 88.08 High High
Inflammatory response 2 80.84 Quite High
Neurotransmitter 1 78.64 Quite High
Disease Link Frequency Relevance Heat
Syndrome 440 99.62 Very High Very High Very High
INFLAMMATION 46 99.40 Very High Very High Very High
Limbic Encephalitis 270 99.18 Very High Very High Very High
Pulmonary Disease 5 98.96 Very High Very High Very High
Isaacs Syndrome 250 98.80 Very High Very High Very High
Hyperalgesia 16 98.72 Very High Very High Very High
Targeted Disruption 20 94.80 High High
Shock 1 91.76 High High
Sleep Disorders 80 89.48 High High
Stress 7 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic obstructive pulmonary diseases (COPD), mucociliary clearance (MC), electro-acupuncture (EA), needle puncture (NP), human neutrophil elastase (HNE), mucociliary transport velocity (MTV), phosphate buffered saline without Ca2+ and Mg2+ (PBS (-))

Competing interests

Localization (saline) of EA in puncture associated with pulmonary disease and acupuncture
1) Confidence 0.43 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397865 Disease Relevance 0.64 Pain Relevance 0.34
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (localization) of Kv1 in hippocampus associated with hippocampus
2) Confidence 0.17 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.96 Pain Relevance 0.31
It is a membrane protein with a large extracellular sequence consisting of multiple well-defined domains (Poliak et al., 1999), and is essential for the co-localization of Kv1.1 and 1.2 at the juxtaparanodes of the nodes of Ranvier.
Localization (localization) of Kv1 in nodes
3) Confidence 0.17 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.46 Pain Relevance 0.11
Previous immunohistological data on a small number of high titre VGKC-antibody positive limbic encephalitis and MorvanÂ’s syndrome sera suggested co-localization with Kv1.1 or 1.2, or occasionally Kv1.6 (Buckley et al., 2001; Liguori et al., 2001; Ances et al., 2005; Antozzi et al., 2005; Kleopa et al., 2006).
Localization (localization) of Kv1 associated with syndrome, limbic encephalitis and potassium channel
4) Confidence 0.17 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.29 Pain Relevance 0.34
In neuromyotonia, early studies suggested that the antibodies were variably directed against these three Kv1 subunits (Hart et al., 1997), and the pathogenic role of purified Immunoglobulin G (IgG) was demonstrated by passive transfer to mice (Sinha et al., 1991; Shillito et al., 1995), and by application to neuronal cell line cultures or Kv1-transfected cells in vitro (Shillito et al., 1995; Nagado et al., 1999; Tomimitsu et al., 2004).
Localization (directed) of Kv1 in neuronal associated with isaacs syndrome
5) Confidence 0.16 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.92 Pain Relevance 0.19
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (confounded) of Kv1 in hippocampus associated with hippocampus
6) Confidence 0.16 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.03 Pain Relevance 0.31
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (confounded) of Kv1 in hippocampus associated with hippocampus
7) Confidence 0.16 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.03 Pain Relevance 0.31
Previous immunohistological data on a small number of high titre VGKC-antibody positive limbic encephalitis and MorvanÂ’s syndrome sera suggested co-localization with Kv1.1 or 1.2, or occasionally Kv1.6 (Buckley et al., 2001; Liguori et al., 2001; Ances et al., 2005; Antozzi et al., 2005; Kleopa et al., 2006).
Localization (localization) of Kv1 associated with syndrome, limbic encephalitis and potassium channel
8) Confidence 0.15 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.29 Pain Relevance 0.35
Methysergide 2.0 mg administered orally partially reversed EA-elicited PRL release, further augmented GH liberation and did not modify TSH output.
Localization (release) of EA
9) Confidence 0.07 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3083453 Disease Relevance 0 Pain Relevance 0.20
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (localization) of Kv1 in cerebellum associated with hippocampus
10) Confidence 0.06 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.96 Pain Relevance 0.31
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (confounded) of Kv1 in cerebellum associated with hippocampus
11) Confidence 0.05 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.03 Pain Relevance 0.31
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (confounded) of Kv1 in cerebellum associated with hippocampus
12) Confidence 0.05 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.03 Pain Relevance 0.31
Thus, we used a CFA-inflamed rat model to test the hypothesis that EA increases glucocorticoid secretion to ameliorate inflammation and hyperalgesia.

2.

Localization (secretion) of EA associated with hyperalgesia, inflammation and electroacupuncture
13) Confidence 0.01 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1976320 Disease Relevance 0.71 Pain Relevance 0.58

General Comments

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