INT34796

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 4.16
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF14) extracellular space (TNFSF14) extracellular region (TNFSF14)
plasma membrane (TNFSF14) cytoplasm (TNFSF14)
Anatomy Link Frequency
plasma 1
macrophages 1
CSF 1
Section 2 1
foam cell 1
TNFSF14 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lamotrigine 23 100.00 Very High Very High Very High
Gabapentin 7 100.00 Very High Very High Very High
Angina 2 99.84 Very High Very High Very High
anticonvulsant 8 99.80 Very High Very High Very High
imagery 2 97.80 Very High Very High Very High
depression 13 97.00 Very High Very High Very High
Inflammatory response 2 93.12 High High
Neuritis 7 92.72 High High
anesthesia 1 92.52 High High
Inflammatory mediators 2 91.28 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 2 99.84 Very High Very High Very High
Manic Depressive Disorder 125 98.68 Very High Very High Very High
Malignant Neoplastic Disease 1 97.16 Very High Very High Very High
Thrombosis 2 97.08 Very High Very High Very High
Depression 16 97.00 Very High Very High Very High
Disease 10 95.28 Very High Very High Very High
Heart Rate Under Development 1 95.12 Very High Very High Very High
Urological Neuroanatomy 1 94.28 High High
Anaemia 1 93.16 High High
INFLAMMATION 5 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, we found an increase in myocin light chain, but not in troponin-T.
Positive_regulation (increase) of light
1) Confidence 0.67 Published 2000 Journal Masui Section Abstract Doc Link 10885250 Disease Relevance 1.07 Pain Relevance 0.39
Myeloma is usually associated with the accumulation of a monoclonal immunoglobulin or light chains in plasma and subsequently an increase in light chains in the urine (Bence-Jones proteins).
Positive_regulation (accumulation) of light in plasma
2) Confidence 0.67 Published 2005 Journal Br Dent J Section Abstract Doc Link 16215569 Disease Relevance 1.08 Pain Relevance 0.09
The single most common laboratory abnormality was an elevated level of free kappa-light chains in CSF.
Positive_regulation (elevated) of light in CSF
3) Confidence 0.49 Published 1986 Journal Arch. Neurol. Section Abstract Doc Link 3083803 Disease Relevance 0.75 Pain Relevance 0.69
In a microarray screening experiment, we identified LIGHT, a ligand in the tumor necrosis factor superfamily, as one of the genes that were markedly upregulated in oxLDL-stimulated THP-1 macrophages.
Positive_regulation (upregulated) of LIGHT in macrophages
4) Confidence 0.41 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis.
Spec (possible) Positive_regulation (Enhanced) of LIGHT in foam cell associated with angina and thrombosis
5) Confidence 0.30 Published 2005 Journal Circulation Section Title Doc Link 16186421 Disease Relevance 0.38 Pain Relevance 0.19
These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
Positive_regulation (activation) of LIGHT
6) Confidence 0.06 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.26 Pain Relevance 0.18
As discussed in Section 2, newer anticonvulsants, such as LTG, TPM and GBP, are effective in the maintenance treatment of BD (LTG) or as add-ons to first line mood stabilizers (TPM, GBP).
Positive_regulation (effective) of LTG in Section 2 associated with manic depressive disorder, lamotrigine, anticonvulsant and gabapentin
7) Confidence 0.02 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.61 Pain Relevance 0.72
Second, the magenta PAP binding loop is much shorter in SULT4A1 than in the other hSULTs, and lacks the conserved Lys residue that separates the key PAPS binding residues Arg258 and Gly260 (SULT1A1 numbering), which results in these residues being out of register.
Positive_regulation (separates) of Arg258
8) Confidence 0.00 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0 Pain Relevance 0

General Comments

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