INT348

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Context Info
Confidence 0.45
First Reported 1978
Last Reported 2006
Negated 3
Speculated 3
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 3.33
Pain Relevance 10.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra1a) aging (Adra1a) plasma membrane (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
vas deferens 2
liver 1
blood 1
thyroid 1
femoral artery 1
Adra1a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 46 100.00 Very High Very High Very High
agonist 48 99.96 Very High Very High Very High
alcohol 1 99.92 Very High Very High Very High
Clonidine 44 99.60 Very High Very High Very High
Potency 3 99.52 Very High Very High Very High
Enkephalin 7 99.32 Very High Very High Very High
cerebral cortex 2 99.28 Very High Very High Very High
cocaine 30 98.68 Very High Very High Very High
Angina 9 98.44 Very High Very High Very High
intrathecal 1 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 12 98.92 Very High Very High Very High
Cv General 3 Under Development 2 98.44 Very High Very High Very High
Cv Unclassified Under Development 4 98.12 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 97.60 Very High Very High Very High
Stress 2 97.56 Very High Very High Very High
Hypertension 7 97.08 Very High Very High Very High
Aggression 1 95.44 Very High Very High Very High
Drug Dependence 2 93.44 High High
Nociception 1 89.36 High High
Hypotension 3 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of alpha-adrenoreceptor stimulation on hepatic glutathione content were examined in ICR male mice using a selective alpha 1-adrenoreceptor stimulating agent, phenylephrine, and a selective alpha 2-adrenoreceptor stimulating drug, clonidine.
Regulation (effects) of alpha-adrenoreceptor associated with clonidine
1) Confidence 0.45 Published 1991 Journal Toxicology Section Abstract Doc Link 1683031 Disease Relevance 0.15 Pain Relevance 0.27
Effects of alpha adrenoreceptor antagonists, prazosin and. yohimbine, on intrathecal lidocaine-induced antinociception in mice.
Regulation (Effects) of alpha adrenoreceptor associated with antinociception, antagonist, lidocaine and intrathecal
2) Confidence 0.45 Published 2000 Journal Acta Anaesthesiol Scand Section Title Doc Link 11028727 Disease Relevance 0.09 Pain Relevance 0.87
The effect of alpha-adrenergic receptor stimulant drugs on amphetamine or apomorphine-induced stereotypy in rats.
Regulation (effect) of alpha-adrenergic receptor
3) Confidence 0.44 Published 1978 Journal Pol J Pharmacol Pharm Section Title Doc Link 33370 Disease Relevance 0 Pain Relevance 0.33
We sought to test the response of the coronary microcirculation to alpha-adrenoceptor blockade in patients with syndrome X (angina, ischemia-like stress electrocardiogram, and a normal coronary arteriogram).
Regulation (response) of alpha-adrenoceptor associated with stress, angina, syndrome and ischemia
4) Confidence 0.43 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10511131 Disease Relevance 0.54 Pain Relevance 0.18
Effect of alpha1-adrenoceptor blockade on coronary vasodilator reserve in cardiac syndrome X.
Regulation (Effect) of alpha1-adrenoceptor associated with syndrome
5) Confidence 0.43 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 10511131 Disease Relevance 0.61 Pain Relevance 0.18
The stainless steel cannula inserting method was used to observe effects of alpha-adrenoceptor agonists, 5-HT and KCl before and after cold storage (3-5 days, at 4 degrees C) in skeletal muscle branches of the simian deep femoral artery.
Regulation (effects) of alpha-adrenoceptor in femoral artery associated with agonist
6) Confidence 0.43 Published 1988 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3379834 Disease Relevance 0.20 Pain Relevance 0.17
Tolazoline and a series of para-substituted analogues were examined in mice to determine the effects of para substitution on alpha-adrenoceptor antagonist potency and tissue disposition. alpha-Adrenoceptor antagonism was measured as abilities to attenuate the hypothermic or sedative actions of clonidine.
Regulation (effects) of alpha-adrenoceptor associated with antagonist, clonidine and potency
7) Confidence 0.36 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2876765 Disease Relevance 0 Pain Relevance 0.32
Effects on alpha-adrenoceptor antagonist properties did not follow a similar pattern.
Regulation (Effects) of alpha-adrenoceptor associated with antagonist
8) Confidence 0.36 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2876765 Disease Relevance 0.12 Pain Relevance 0.45
However, the effects of alpha-adrenoceptor activation on cerebellar inhibitory neurotransmission have not yet been fully elucidated.
Regulation (effects) of alpha-adrenoceptor
9) Confidence 0.35 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16251261 Disease Relevance 0 Pain Relevance 0.29
The effects of various alpha-adrenoceptor agonists and antagonists on blood radioiodine levels were studied in mice pre-treated with 125I and thyroxine.
Regulation (effects) of alpha-adrenoceptor in blood associated with antagonist and agonist
10) Confidence 0.32 Published 1985 Journal Acta Endocrinol. Section Abstract Doc Link 2857513 Disease Relevance 0 Pain Relevance 0.54
Effects of alpha-adrenoceptor agonists and antagonists on thyroid hormone secretion.
Regulation (Effects) of alpha-adrenoceptor in thyroid associated with antagonist and agonist
11) Confidence 0.32 Published 1985 Journal Acta Endocrinol. Section Title Doc Link 2857513 Disease Relevance 0 Pain Relevance 0.77
The study suggests that alpha-adrenergic and enkephalin receptors may share some common regulatory pathways but opiate peptides and antagonists selectively decrease or increase the density of enkephalin receptors, respectively, with no effect on alpha-adrenergic receptor density.
Neg (no) Regulation (effect) of alpha-adrenergic receptor associated with antagonist, opiate and enkephalin
12) Confidence 0.27 Published 1982 Journal Life Sci. Section Abstract Doc Link 6292623 Disease Relevance 0.11 Pain Relevance 1.18
These data indicate that chronic haloperidol does not cause a generalized change in alpha-adrenergic receptor sensitivity.
Regulation (change) of alpha-adrenergic receptor
13) Confidence 0.26 Published 1983 Journal J. Neural Transm. Section Abstract Doc Link 6619828 Disease Relevance 0.32 Pain Relevance 0.31
Thus, the difference in fractional NA release between the basilar and ear arteries cannot be accounted for by differences in prejunctional alpha-adrenoreceptor modulation.
Regulation (modulation) of alpha-adrenoreceptor in ear associated with noradrenaline
14) Confidence 0.26 Published 1982 Journal J Auton Pharmacol Section Abstract Doc Link 6288723 Disease Relevance 0 Pain Relevance 0.62
The influence of alpha-adrenoceptor subtypes on Na+ transport in distal convoluted tubules (DCT) has not been examined due to the difficulty of isolating and quantifying responses in this segment.
Regulation (influence) of alpha-adrenoceptor in distal convoluted tubules
15) Confidence 0.17 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8238385 Disease Relevance 0 Pain Relevance 0.18
Alpha adrenoceptor block by prazosin (10 nM) or the irreversible antagonist benextramine tetrahydrochloride did not affect responses to 5-HT or ergometrine.
Neg (not) Regulation (affect) of Alpha adrenoceptor associated with antagonist
16) Confidence 0.16 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6114172 Disease Relevance 0.17 Pain Relevance 0.21
MIL did not change the number or affinity (Bmax and K(D)) of alpha1-adrenergic receptors in the cerebral cortex for [3H]prazonsin, however, the ability of the alpha1-adrenoceptor agonist phenylephrine to compete for these sites was significantly enhanced.
Neg (not) Regulation (change) of alpha1-adrenergic in cerebral cortex associated with agonist and cerebral cortex
17) Confidence 0.11 Published 2000 Journal J Neural Transm Section Abstract Doc Link 11145008 Disease Relevance 0.19 Pain Relevance 0.48
Effects of methoxamine, and alpha-1 adrenoceptor agonist, and prazosin, an alpha-1 antagonist, on the stages of the sleep-waking cycle in the cat.
Regulation (Effects) of alpha-1 adrenoceptor associated with antagonist and agonist
18) Confidence 0.10 Published 1984 Journal Acta Physiol. Scand. Section Title Doc Link 6146242 Disease Relevance 0.05 Pain Relevance 0.23
The results support a role for norepinephrine uptake and alpha-1 adrenoceptor mechanisms in the DS effects of cocaine, possibly reflecting a facilitory noradrenergic influence on mesocorticolimbic dopamine activity.
Spec (possibly) Regulation (role) of alpha-1 adrenoceptor associated with dopamine and cocaine
19) Confidence 0.10 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562595 Disease Relevance 0 Pain Relevance 0.58
1 The effects of several drugs upon the excitatory junction potential (e.j.p.) in the guinea-pig vas deferens have been investigated. 2 Amiodarone, a noradrenergic neurone blocker which also blocks both alpha and beta-adrenoreceptors, did not reduce the e.j.p. 3 The alpha-adrenoreceptor antagonists, azapetine, piperoxan and prazosin, only enhanced the e.j.p. irrespective of their relative potencies at alpha 1 and alpha 2-adrenoreceptors. 4 Sotalol, a beta-adrenoreceptor antagonist, was without effect upon the e.j.p. 5 Clonidine and lysergic acid diethylamide, alpha-adrenoreceptor agonists, produced a dose dependent inhibition of the e.j.p. without apparently affecting the frequency or size of spontaneous junction potentials. 6 The effects of clonidine were antagonized by piperoxan in a competitive reversible manner. 7 It is argued that these results confirm the presence of alpha-adrenoreceptors prejunctionally upon the sympathetic excitatory innervation of the vas deferens but that although an endogenous alpha-adrenoreceptor agonist is released by nerve stimulation either the transmitter that is responsible for the e.j.p. is not noradrenaline or that the postjunctional receptors responsible for the generation of the e.j.p. are not adrenoreceptors.
Regulation (although) of endogenous alpha-adrenoreceptor in vas deferens associated with antagonist, noradrenaline, agonist and clonidine
20) Confidence 0.08 Published 1981 Journal J Auton Pharmacol Section Abstract Doc Link 6123511 Disease Relevance 0 Pain Relevance 0.42

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