INT348028

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Traf3, Ticam1) endosome (Traf3) signal transducer activity (Ticam1)
ligase activity (Traf3) cytoplasm (Traf3)
Anatomy Link Frequency
nucleus 1
Traf3 (Mus musculus)
Ticam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 23 69.28 Quite High
cytokine 10 19.04 Low Low
fibrosis 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 4 81.92 Quite High
INFLAMMATION 23 69.28 Quite High
Hepatitis B Virus Infection 8 60.88 Quite High
Hepatitis C Virus Infection 8 60.48 Quite High
Alcoholic Liver Diseases 2 60.08 Quite High
Nash(non-alcoholic Steatohepatitis) 9 57.76 Quite High
Hepatocellular Cancer 47 55.04 Quite High
Targeted Disruption 13 49.76 Quite Low
Cancer 40 5.00 Very Low Very Low Very Low
Apoptosis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR3 and TLR4 both signal through the TRIF adaptor, which interacts with TRAF3 to activate the nonclassical IKKs and the IKK, resulting in the dimerization and activation of IRF3, which then translocates to the nucleus activating the transcription of IFN and IFN-induced genes [78].

5.2.

TRAF3 Binding (interacts) of TRIF adaptor in nucleus
1) Confidence 0.01 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.56 Pain Relevance 0.03

General Comments

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