INT348038

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos, Hltf) DNA binding (Fos, Hltf) ATPase activity (Hltf)
helicase activity (Hltf) transcription factor binding (Fos) ligase activity (Hltf)
Fos (Mus musculus)
Hltf (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 60.08 Quite High
Inflammation 23 27.04 Quite Low
chemokine 1 23.44 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 47 92.28 High High
Apoptosis 11 81.12 Quite High
Liver Cancer 3 54.48 Quite High
Cancer 40 46.32 Quite Low
Hepatitis C Virus Infection 8 43.20 Quite Low
Hepatitis B Virus Infection 8 42.88 Quite Low
INFLAMMATION 23 27.04 Quite Low
Targeted Disruption 13 10.80 Low Low
Nash(non-alcoholic Steatohepatitis) 9 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The AP-1 transcription factors, c-Jun and c-Fos, are composed of homo- and heterodimers with basic region-leucine zipper proteins belonging to the Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra-1, and Fra-2) subfamilies, all of which recognize the AP-1 binding site or TPA-response element in the regulatory region of AP-1 target genes [69].
Fos Binding (recognize) of TPA-response element
1) Confidence 0.01 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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