INT348135

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPE)
Anatomy Link Frequency
neurons 2
GYPE (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 3 96.04 Very High Very High Very High
Dopamine 33 90.64 High High
GABAergic 11 76.20 Quite High
cerebral cortex 5 59.32 Quite High
antagonist 4 26.52 Quite Low
medulla 3 20.48 Low Low
agonist 6 18.56 Low Low
Thalamus 10 5.00 Very Low Very Low Very Low
Pyramidal cell 9 5.00 Very Low Very Low Very Low
Raphe 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 4 99.32 Very High Very High Very High
Targeted Disruption 4 71.28 Quite High
Sleep Disorders 26 5.00 Very Low Very Low Very Low
Disease 26 5.00 Very Low Very Low Very Low
Parkinson's Disease 7 5.00 Very Low Very Low Very Low
Weight Loss 6 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Generalized Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Infarction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It can therefore be inferred that the loss of D2 postsynaptic and presynaptic inhibition in the striatum and GPe would result in hyperactivity of the striatopallidal neurons, resulting in inhibition (presumably GABA-mediated) of the GPe neurons, which would then result in increased arousal.
Negative_regulation (loss) of Negative_regulation (inhibition) of GPe in neurons associated with gaba and attention deficit hyperactivity disorder
1) Confidence 0.05 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0.17 Pain Relevance 0.39

General Comments

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