INT348145

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 6.72
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1) cytoplasm (Thbs1)
Anatomy Link Frequency
astrocytes 4
brains 2
extracellular matrix 1
nervous system 1
Thbs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 13 83.92 Quite High
imagery 26 61.64 Quite High
Gabapentin 13 33.76 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 1573 99.84 Very High Very High Very High
Stroke 26 96.72 Very High Very High Very High
Generaliased Trisomy 13 77.64 Quite High
Intellectual Impairment 39 66.84 Quite High
Cognitive Disorder 52 48.08 Quite Low
Stress 52 43.48 Quite Low
Parkinson's Disease 52 42.64 Quite Low
Cancer 13 26.92 Quite Low
Congenital Anomalies 52 5.00 Very Low Very Low Very Low
Disease 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aliquots of CM from the same cultures were processed to determine the level of secreted TSP-1.
Spec (determine) Localization (secreted) of TSP-1
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0
To determine whether depletion of TSP-1 is sufficient to alter spine number and morphology, NL astrocyte/hippocampal neuron cocultures were treated with anti-TSP-1 antibody to neutralize the endogenous TSP-1 secreted by NL human astrocytes.
Localization (secreted) of TSP-1 in astrocytes
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.11 Pain Relevance 0
TSP-1 measurements
Localization (measurements) of TSP-1
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0.06
We also show that thrombospondin 1 (TSP-1), an astrocyte-secreted protein, possesses a potent modulatory effect on spine number and morphology, and that both DS brains and DS astrocytes exhibit marked deficits in TSP-1 protein expression.
Localization (astrocyte-secreted protein) of TSP-1 in brains associated with syndrome
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2996288 Disease Relevance 0.99 Pain Relevance 0
Given that TSP-1 is one of the most abundant proteins secreted by human astrocytes (data not shown), and that there are marked deficits in protein secretion in DS astrocytes [22], we next analyzed TSP-1 expression and secretion in DS astrocyte cultures and brain homogenates.
Localization (secreted) of TSP-1 in astrocyte associated with syndrome
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.85 Pain Relevance 0
TSP-1 is an extracellular matrix protein synthesized and released by astrocytes [26], which is highly expressed during development of the nervous system [27].
Localization (released) of TSP-1 in extracellular matrix
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.78 Pain Relevance 0
The lysates were centrifuged at 14,000 rpm in an Eppendorf microcentrifuge for 30 min at 4°C, and the supernatants were used to determine the intracellular concentration of TSP-1.
Spec (determine) Localization (concentration) of TSP-1
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0
We also show that thrombospondin 1 (TSP-1), an astrocyte-secreted protein, possesses a potent modulatory effect on spine number and morphology, and that both DS brains and DS astrocytes exhibit marked deficits in TSP-1 protein expression.
Localization (astrocyte-secreted protein) of thrombospondin 1 in brains associated with syndrome
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2996288 Disease Relevance 1.00 Pain Relevance 0
Furthermore, interferons also inhibit protein glycosylation [111], which is required for TSP-1 secretion.
Localization (secretion) of TSP-1
9) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.85 Pain Relevance 0.04
Given that TSP-1 is one of the most abundant proteins secreted by human astrocytes (data not shown), and that there are marked deficits in protein secretion in DS astrocytes [22], we next analyzed TSP-1 expression and secretion in DS astrocyte cultures and brain homogenates.
Spec (analyzed) Localization (secretion) of TSP-1 in astrocytes associated with syndrome
10) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.85 Pain Relevance 0
Human astrocytes synthesize and secrete TSP-1, an extracellular matrix component involved in cell-cell and cell-matrix communication [26], [78], which is widely expressed in the developing nervous system [27].
Localization (secrete) of TSP-1 in nervous system
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.34 Pain Relevance 0
TSP-1 subcellular localization and staining pattern was similar in normal and DS astrocytes.
Localization (localization) of TSP-1 in astrocytes associated with syndrome
12) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.95 Pain Relevance 0
Starting at day 7, anti-TSP-1 (1?
Localization (Starting) of TSP-1
13) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0

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