INT348146

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 2.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Thbs1) cytoplasm (Thbs1)
Anatomy Link Frequency
spine 2
neuronal 1
neurons 1
adult brain 1
Thbs1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Gabapentin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 726 99.44 Very High Very High Very High
Stroke 12 98.44 Very High Very High Very High
Apoptosis 6 9.36 Low Low
Parkinson's Disease 24 5.00 Very Low Very Low Very Low
Cognitive Disorder 24 5.00 Very Low Very Low Very Low
Stress 24 5.00 Very Low Very Low Very Low
Congenital Anomalies 24 5.00 Very Low Very Low Very Low
Disease 24 5.00 Very Low Very Low Very Low
Intellectual Impairment 18 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Control cultures were incubated with heat-inactivated TSP-1 (100°C for 5 min).
Positive_regulation (inactivated) of TSP-1
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0 Pain Relevance 0
TSP-1 increases synaptic density and activity in neurons grown on top of DS astrocytes
Positive_regulation (increases) of TSP-1 in neurons associated with syndrome
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.65 Pain Relevance 0
Heat-inactivated TSP-1 did not have any effect on spine morphology or number (Figure 6A and B).
Positive_regulation (inactivated) of TSP-1 in spine
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.17 Pain Relevance 0
TSP-1 expression was considerably higher in fetal than in adult brain homogenates (data not shown), consistent with a significant role of TSP-1 during development [27].
Positive_regulation (role) of TSP-1 in adult brain
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.79 Pain Relevance 0
Anti-TSP-1 previously neutralized with excess TSP-1 and non-immune IgG had no effect on spine morphology (data not shown).
Positive_regulation (excess) of TSP-1 in spine
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.09 Pain Relevance 0
Recently, it has been demonstrated that TSP-1 is necessary for synaptic and motor recovery after stroke [33], suggesting that TSP-1 also participates in neuronal plasticity.
Positive_regulation (necessary) of TSP-1 in neuronal associated with stroke
6) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.71 Pain Relevance 0

General Comments

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