INT348166

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (DLG4) plasma membrane (DLG4) protein complex assembly (DLG4)
Anatomy Link Frequency
spines 1
synapses 1
DLG4 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Gabapentin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 363 97.48 Very High Very High Very High
Parkinson's Disease 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Congenital Anomalies 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Intellectual Impairment 9 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the total number of synapses in the culture, represented by synaptophysin/PSD95 colocalization (Figure 8A and B), more than 50% were localized at dendritic spines, represented by synaptophysin/PSD95/drebrin colocalization (Figure 8C and D), indicating that spines are principal sites of synaptic formation in the cocultures.
Localization (colocalization) of PSD95 in spines
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.40 Pain Relevance 0
To determine the number of synapses specifically localized in spines (Figure 8C), we measured the frequency of colocalization of synaptophysin, PSD95 and drebrin, (Figure 8D and Figure S4).
Localization (colocalization) of PSD95 in synapses
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.37 Pain Relevance 0
Synaptic density was assessed as the frequency of colocalization of the pre- and post-synaptic markers synaptophysin and PSD95 at 21 DIV [37]–[39].
Localization (colocalization) of PSD95
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.36 Pain Relevance 0

General Comments

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