INT348173

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-B, IL23R)
HLA-B (Homo sapiens)
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 41 96.80 Very High Very High Very High
Inflammation 9 90.44 High High
spondylitis 2 50.00 Quite Low
rheumatoid arthritis 4 46.48 Quite Low
Crohn's disease 15 42.24 Quite Low
psoriasis 4 30.08 Quite Low
Arthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ankylosing Spondylitis 42 96.80 Very High Very High Very High
Disease 34 96.48 Very High Very High Very High
Rheumatic Diseases 1 91.20 High High
INFLAMMATION 4 90.44 High High
Rheumatoid Arthritis 4 46.48 Quite Low
Diabetes Mellitus 5 43.76 Quite Low
Inflammatory Bowel Disease 25 33.04 Quite Low
Psoriasis 4 30.08 Quite Low
Ileitis 2 13.76 Low Low
Spondylarthritis 1 9.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apart from the well known HLA-B27 association, recent genetic studies have identified ERAP1, IL23R and 2 intergenic regions at chr2p15 and chr21q22 as genes/loci associated with AS [3], [4].
HLA-B27 Binding (association) of IL23R associated with spinal inflammation
1) Confidence 0.15 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.92 Pain Relevance 0.49

General Comments

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